Literature DB >> 8391840

Expression of alpha isoforms of the Na,K-ATPase in human heart.

R Zahler1, M Gilmore-Hebert, J C Baldwin, K Franco, E J Benz.   

Abstract

We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5%, alpha 1, 15% alpha 2 and 22.5% alpha 3 on average. There was an increase in expression of the alpha 3 isoform in samples from failing hearts, but expression of all three isoforms decreased in pressure-overloaded right ventricle (RV).

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Year:  1993        PMID： 8391840     DOI： 10.1016/0005-2736(93)90200-j

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  18 in total

1.  Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.

Authors:  N Vrbjar; I Bernátová; O Pechánová
Journal:  Mol Cell Biochem       Date:  1999-12       Impact factor: 3.396

2.  Functional antagonism by a monoclonal antibody to digoxin in a test system of cultured rat heart myocytes.

Authors:  G Wallukat; H U Simon; W D Müller; I Wolf
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

3.  Localization of alpha 1,2,3-subunit isoforms of Na,K-ATPase in cultured neonatal and adult rat myocardium: the immunofluorescence and immunocytochemical study.

Authors:  J Slezak; W Schulze; Z Stefankova; L Okruhlicova; L Danihel; G Wallukat
Journal:  Mol Cell Biochem       Date:  1996 Oct-Nov       Impact factor: 3.396

4.  Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes.

Authors:  Sanda Despa; Jerry B Lingrel; Donald M Bers
Journal:  Cardiovasc Res       Date:  2012-06-27       Impact factor: 10.787

5.  Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes.

Authors:  Garrick K Yuen; Samuel Galice; Donald M Bers
Journal:  J Mol Cell Cardiol       Date:  2017-06-03       Impact factor: 5.000

6.  Cardiac sarcolemmal Na(+)-Ca2+ exchange and Na(+)-K+ ATPase activities and gene expression in alloxan-induced diabetes in rats.

Authors:  L Golfman; I M Dixon; N Takeda; A Lukas; K Dakshinamurti; N S Dhalla
Journal:  Mol Cell Biochem       Date:  1998-11       Impact factor: 3.396

7.  Na, K-ATPase isoform gene expression in normal and hypertrophied dog heart.

Authors:  R Zahler; M Gilmore-Hebert; W Sun; E J Benz
Journal:  Basic Res Cardiol       Date:  1996 May-Jun       Impact factor: 17.165

8.  Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart.

Authors:  J Wang; R H Schwinger; K Frank; J Müller-Ehmsen; P Martin-Vasallo; T A Pressley; A Xiang; E Erdmann; A A McDonough
Journal:  J Clin Invest       Date:  1996-10-01       Impact factor: 14.808

Review 9.  Na⁺ transport in the normal and failing heart - remember the balance.

Authors:  Sanda Despa; Donald M Bers
Journal:  J Mol Cell Cardiol       Date:  2013-04-19       Impact factor: 5.000

10.  The expression of the human neuronal alpha3 Na+,K+-ATPase subunit gene is regulated by the activity of the Sp1 and NF-Y transcription factors.

Authors:  Roberta Benfante; Ruth Adele Antonini; Monica Vaccari; Adriano Flora; Fabian Chen; Francesco Clementi; Diego Fornasari
Journal:  Biochem J       Date:  2005-02-15       Impact factor: 3.857
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