PURPOSE: To evaluate the efficacy of dynamic susceptibility-contrast magnetic resonance (MR) imaging for diagnosis of intraaxial brain tumors. MATERIALS AND METHODS: Ten patients with such tumors (two hemangioblastomas, five low-grade astrocytomas, and three glioblastomas) underwent examination at 1.5 T. After bolus injection of 0.15 mmol/kg gadopentetate dimeglumine, gradient-echo MR images were obtained every 3.6 seconds for 90 seconds. Region-of-interest analyses were performed in all tumors. RESULTS: The greatest loss in signal intensity during the first pass of the contrast agent was seen in hemangioblastomas; low-grade astrocytomas had the least loss. The differences in integration of change in the T2* relaxation rate were significant among the three types of tumor (hemangioblastomas vs low-grade astrocytomas, P < .001; hemangioblastomas vs glioblastomas, P < .005; and glioblastomas vs low-grade astrocytomas, P < .02) and indicated differences in vascularity. CONCLUSION: Dynamic susceptibility-contrast MR imaging can provide useful hemodynamic information about intraaxial brain tumors that is not provided by standard MR imaging and therefore contributes to the differential diagnosis.
PURPOSE: To evaluate the efficacy of dynamic susceptibility-contrast magnetic resonance (MR) imaging for diagnosis of intraaxial brain tumors. MATERIALS AND METHODS: Ten patients with such tumors (two hemangioblastomas, five low-grade astrocytomas, and three glioblastomas) underwent examination at 1.5 T. After bolus injection of 0.15 mmol/kg gadopentetate dimeglumine, gradient-echo MR images were obtained every 3.6 seconds for 90 seconds. Region-of-interest analyses were performed in all tumors. RESULTS: The greatest loss in signal intensity during the first pass of the contrast agent was seen in hemangioblastomas; low-grade astrocytomas had the least loss. The differences in integration of change in the T2* relaxation rate were significant among the three types of tumor (hemangioblastomas vs low-grade astrocytomas, P < .001; hemangioblastomas vs glioblastomas, P < .005; and glioblastomas vs low-grade astrocytomas, P < .02) and indicated differences in vascularity. CONCLUSION: Dynamic susceptibility-contrast MR imaging can provide useful hemodynamic information about intraaxial brain tumors that is not provided by standard MR imaging and therefore contributes to the differential diagnosis.
Authors: H Uematsu; M Maeda; N Sadato; T Matsuda; Y Ishimori; Y Koshimoto; H Kimura; H Yamada; Y Kawamura; Y Yonekura; H Itoh Journal: AJNR Am J Neuroradiol Date: 2001 Nov-Dec Impact factor: 3.825
Authors: Peter S LaViolette; Alex D Cohen; Melissa A Prah; Scott D Rand; Jennifer Connelly; Mark G Malkin; Wade M Mueller; Kathleen M Schmainda Journal: Neuro Oncol Date: 2013-02-03 Impact factor: 12.300
Authors: Kathleen M Schmainda; Melissa Prah; Jennifer Connelly; Scott D Rand; Raymond G Hoffman; Wade Mueller; Mark G Malkin Journal: Neuro Oncol Date: 2014-01-15 Impact factor: 12.300
Authors: Barjor Gimi; Arvind P Pathak; Ellen Ackerstaff; Kristine Glunde; Dmitri Artemov; Zaver M Bhujwalla Journal: Proc IEEE Inst Electr Electron Eng Date: 2005-04-01 Impact factor: 10.961