Literature DB >> 8370378

Dosimetry of iodine-123 iomazenil in humans.

N P Verhoeff1, E Busemann Sokole, D Hengst, J B Stubbs, E A van Royen.   

Abstract

The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq.

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Year:  1993        PMID： 8370378     DOI： 10.1007/bf00176551

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  13 in total

1.  Benzodiazepine receptors and cerebral blood flow in partial epilepsy.

Authors:  P Bartenstein; A Ludolph; O Schober; G Lottes; K Scheidhauer; J Sciuk; H F Beer
Journal:  Eur J Nucl Med       Date:  1991

2.  In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci.

Authors:  I Savic; A Persson; P Roland; S Pauli; G Sedvall; L Widén
Journal:  Lancet       Date:  1988-10-15       Impact factor: 79.321

3.  Population radiation absorbed dose from nuclear medicine procedures in The Netherlands.

Authors:  H Beekhuis
Journal:  Health Phys       Date:  1988-03       Impact factor: 1.316

4.  The story and activity of flumazenil (Anexate).

Authors:  W E Haefely
Journal:  Acta Anaesthesiol Belg       Date:  1989

5.  Use of ionizing radiation and radionuclides on human beings for medical research, training, and nonmedical purposes. Report of a WHO Expert Committee.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  1977

6.  Dose to the fetus from radionuclides in the bladder.

Authors:  R J Cloutier; S A Smith; E E Watson; W S Snyder; G G Warner
Journal:  Health Phys       Date:  1973-08       Impact factor: 1.316

7.  Quantification of central benzodiazepine receptor binding potential in the brain with 123I-iomazenil SPECT: technical and interobserver variability.

Authors:  N P Verhoeff; B Erbas; O Kapucu; E Busemann Sokole; H Blok; E A Van Royen
Journal:  Nucl Med Commun       Date:  1993-08       Impact factor: 1.690

8.  Effective dose equivalent from radiopharmaceuticals.

Authors:  L Johansson; S Mattsson; B Nosslin
Journal:  Eur J Nucl Med       Date:  1984

9.  Population characteristics and absorbed dose to the population from nuclear medicine: United States--1982.

Authors:  F A Mettler; J H Christie; A G Williams; R D Moseley; C A Kelsey
Journal:  Health Phys       Date:  1986-05       Impact factor: 1.316

10.  Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET.

Authors:  S Pappata; Y Samson; C Chavoix; C Prenant; M Mazière; J C Baron
Journal:  J Cereb Blood Flow Metab       Date:  1988-06       Impact factor: 6.200
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  2 in total

1.  The dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane.

Authors:  J T Kuikka; K A Bergström; A Ahonen; E Länsimies
Journal:  Eur J Nucl Med       Date:  1994-01

2.  Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT. A preliminary report.

Authors:  S Schlegel; H Steinert; A Bockisch; K Hahn; R Schloesser; O Benkert
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270
  2 in total

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