Literature DB >> 8088286

The dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane.

J T Kuikka1, K A Bergström, A Ahonen, E Länsimies.   

Abstract

This report documents the radiation dosimetry of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane [123I]beta-CIT in humans. The mean absorbed doses for various organs and the effective dose equivalent were estimated from whole-body scans, blood samples and single-photon emission tomography scans acquired up to 22 h after the injection of a known amount of tracer. The basal ganglia, the liver and the lower large intestinal wall received the highest mean absorbed doses of 0.270 mGy/MBq, 0.038 mGy/MBq and 0.034 mGy/MBq, respectively. The effective dose equivalent for adults was estimated using 11 organs and the ICRP-87 radiation dose model and was 0.031 mSv/MBq. The radiation dose to the basal ganglia limits the maximum injected activity of [125I]beta-CIT to 185 MBq for a single study.

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Year:  1994        PMID： 8088286     DOI： 10.1007/bf00182306

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  6 in total

1.  Single photon emission computed tomography imaging of monoamine reuptake sites in primate brain with [123I]CIT.

Authors:  R Innis; R Baldwin; E Sybirska; Y Zea; M Laruelle; M al-Tikriti; D Charney; S Zoghbi; E Smith; G Wisniewski
Journal:  Eur J Pharmacol       Date:  1991-08-06       Impact factor: 4.432

2.  Absorbed fractions for small volumes containing photon-emitting radioactivity.

Authors:  W H Ellett; R M Humes
Journal:  J Nucl Med       Date:  1971-03       Impact factor: 10.057

3.  Physical performance of the Siemens MultiSPECT 3 gamma camera.

Authors:  J T Kuikka; M Tenhunen-Eskelinen; J Jurvelin; H Kiiliänen
Journal:  Nucl Med Commun       Date:  1993-06       Impact factor: 1.690

4.  [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.

Authors:  J L Neumeyer; S Y Wang; R A Milius; R M Baldwin; Y Zea-Ponce; P B Hoffer; E Sybirska; M al-Tikriti; D S Charney; R T Malison
Journal:  J Med Chem       Date:  1991-10       Impact factor: 7.446

5.  Initial experience with single-photon emission tomography using iodine-123-labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane in human brain.

Authors:  J T Kuikka; K A Bergström; E Vanninen; V Laulumaa; P Hartikainen; E Länsimies
Journal:  Eur J Nucl Med       Date:  1993-09

6.  Dosimetry of iodine-123 iomazenil in humans.

Authors:  N P Verhoeff; E Busemann Sokole; D Hengst; J B Stubbs; E A van Royen
Journal:  Eur J Nucl Med       Date:  1993-07
  6 in total
  14 in total

1.  Cluster C personality disorder has no independent effect on striatal dopamine transporter densities in major depression.

Authors:  T Laasonen-Balk; H Viinamäki; J Kuikka; M Husso-Saastamoinen; J Lehtonen; P Halonen; J Tiihonen
Journal:  Psychopharmacology (Berl)       Date:  2001-04       Impact factor: 4.530

2.  A novel computer-assisted image analysis of [123I]β-CIT SPECT images improves the diagnostic accuracy of parkinsonian disorders.

Authors:  Georg Goebel; Klaus Seppi; Eveline Donnemiller; Boris Warwitz; Gregor K Wenning; Irene Virgolini; Werner Poewe; Christoph Scherfler
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-12-21       Impact factor: 9.236

3.  beta-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo.

Authors:  W Pirker; S Asenbaum; S Kasper; H Walter; P Angelberger; G Koch; A Pozzera; L Deecke; I Podreka; T Brücke
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [123I]β-CIT SPECT.

Authors:  Michael Nocker; Klaus Seppi; Eveline Donnemiller; Irene Virgolini; Gregor K Wenning; Werner Poewe; Christoph Scherfler
Journal:  Eur J Nucl Med Mol Imaging       Date:  2012-03-30       Impact factor: 9.236

5.  Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysis.

Authors:  Christoph Scherfler; Sylvia M Boesch; Eveline Donnemiller; Klaus Seppi; Helga Weirich-Schwaiger; Georg Goebel; Irene Virgolini; Gregor K Wenning; Werner Poewe
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-05-13       Impact factor: 9.236

6.  EANM procedure guidelines for brain neurotransmission SPECT using (123)I-labelled dopamine transporter ligands, version 2.

Authors:  Jacques Darcourt; Jan Booij; Klaus Tatsch; Andrea Varrone; Thierry Vander Borght; Ozlem L Kapucu; Kjell Någren; Flavio Nobili; Zuzana Walker; Koen Van Laere
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-02       Impact factor: 9.236

7.  Usefulness of brain 99mTc-TRODAT-1 SPET for the evaluation of Parkinson's disease.

Authors:  Wen-Sheng Huang; Meei-Shyuan Lee; Jiann-Chyun Lin; Cheng-Yu Chen; Yu-Wen Yang; Shinn-Zong Lin; Shiaw-Pyng Wey
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-02       Impact factor: 9.236

8.  Imaging of serotonin and dopamine transporters in the living human brain.

Authors:  J T Kuikka; J Tiihonen; K A Bergström; J Karhu; P Hartikainen; H Viinamäki; E Länsimies; J Lehtonen; P Hakola
Journal:  Eur J Nucl Med       Date:  1995-04

9.  Comparison of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain.

Authors:  J T Kuikka; K A Bergström; A Ahonen; J Hiltunen; J Haukka; E Länsimies; S Wang; J L Neumeyer
Journal:  Eur J Nucl Med       Date:  1995-04

10.  Iodine-123 labelled N-(2-fluoroethyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain.

Authors:  J T Kuikka; K Akerman; K A Bergström; J Karhu; J Hiltunen; J Haukka; J Heikkinen; J Tiihonen; S Wang; J L Neumeyer
Journal:  Eur J Nucl Med       Date:  1995-07
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