Literature DB >> 83650

Interaction of bleomycin with DNA.

M Takeshita, A P Grollman, E Ohtsubo, H Ohtsubo.   

Abstract

The sequence of oligonucleotides produced by the action of bleomycin and ferrous ion on double- and single-stranded DNA has been determined. In the presence of ferrous ion, bleomycin promotes cleavage at G-T and G-C sequences, while high concentrations of ferrous ion alone result in strand scission that is not base specific. In the presence of bleomycin and ferrous ion, pyrimidine bases located to the 3' side of guanosine are released preferentially and a low molecular weight product that forms a chromophore with thiobarbituric acid is produced from the deoxyribose moiety. Oligonucleotides produced by the action of bleomycin differ slightly in electrophoretic mobility from those produced by chemical or enzymatic cleavage. A model is proposed to explain the interactions of bleomycin with DNA.

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Year:  1978        PMID： 83650      PMCID： PMC393101          DOI： 10.1073/pnas.75.12.5983

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Studies on the resistance of desoxyribonucleic acids to physical and chemical factors.

Authors:  S ZAMENHOF; G GRIBOFF; N MARULLO
Journal:  Biochim Biophys Acta       Date:  1954-04

2.  Nucleotide specificity in DNA scission by neocarzinostatin.

Authors:  T Hatayama; I H Goldberg; M Takeshita; A P Grollman
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

3.  Nucleotide sequence of bacteriophage phi X174 DNA.

Authors:  F Sanger; G M Air; B G Barrell; N L Brown; A R Coulson; C A Fiddes; C A Hutchison; P M Slocombe; M Smith
Journal:  Nature       Date:  1977-02-24       Impact factor: 49.962

4.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

5.  Nucleotide sequence of an insertion element, IS1.

Authors:  H Ohtsubo; E Ohtsubo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

6.  A simple method of preparing large amounts of phiX174 RF 1 supercoiled DNA.

Authors:  G N Godson; D Vapnek
Journal:  Biochim Biophys Acta       Date:  1973-04-11

7.  Bleomycin, an inhibitor of vaccinia virus replication.

Authors:  M Takeshita; S B Horwitz; A P Grollman
Journal:  Virology       Date:  1974-08       Impact factor: 3.616

8.  Action of bleomycin on DNA and RNA.

Authors:  W E Müller; Z Yamazaki; H J Breter; R K Zahn
Journal:  Eur J Biochem       Date:  1972-12-18

9.  Release of free bases from deoxyribonucleic acid after reaction with bleomycin.

Authors:  C W Haidle; K K Weiss; M T Kuo
Journal:  Mol Pharmacol       Date:  1972-09       Impact factor: 4.436

10.  Characterization of bleomycin-resistant DNA.

Authors:  M Tien Kuo; C W Haidle; L D Inners
Journal:  Biophys J       Date:  1973-12       Impact factor: 4.033
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  52 in total

1.  An in vitro approach to study chromosomal DNA damage.

Authors:  M Bala; L Mathew
Journal:  Mol Biol Rep       Date:  2001       Impact factor: 2.316

2.  Group I intron renders differential susceptibility of Candida albicans to Bleomycin.

Authors:  Prathiba Jayaguru; Malathi Raghunathan
Journal:  Mol Biol Rep       Date:  2006-11-07       Impact factor: 2.316

3.  Studying the effect of a charged surface on the interaction of bleomycin with DNA using an atomic force microscope.

Authors:  Olivier Piétrement; David Pastré; Fabrice Landousy; Marie-Odile David; Stéphane Fusil; Loïc Hamon; Alain Zozime; Eric Le Cam
Journal:  Eur Biophys J       Date:  2004-11-05       Impact factor: 1.733

4.  Effects of hypoxanthine substitution on bleomycin-mediated DNA strand degradation in DNA-RNA hybrids.

Authors:  M Bansal; J Stubbe; J W Kozarich
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

5.  Comparison of the sequence specificity of bleomycin cleavage in two slightly different DNA sequences.

Authors:  V Murray; R F Martin
Journal:  Nucleic Acids Res       Date:  1985-03-11       Impact factor: 16.971

6.  The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence.

Authors:  Shweta D Gautam; Jon K Chen; Vincent Murray
Journal:  J Biol Inorg Chem       Date:  2017-05-16       Impact factor: 3.358

7.  Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322.

Authors:  R C Hawley; L L Kiessling; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

8.  Novel DNA photocleaving agents with high DNA sequence specificity related to the antibiotic bleomycin A2.

Authors:  R Kuroda; H Satoh; M Shinomiya; T Watanabe; M Otsuka
Journal:  Nucleic Acids Res       Date:  1995-05-11       Impact factor: 16.971

9.  Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II).

Authors:  M W Van Dyke; R P Hertzberg; P B Dervan
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

10.  Bleomycin mediated degradation of DNA-RNA hybrids does not involve C-1' chemistry.

Authors:  M J Absalon; C R Krishnamoorthy; G McGall; J W Kozarich; J Stubbe
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971
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