Literature DB >> 8359887

The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins.

T F Rinke de Wit1, S Bekelie, A Osland, B Wieles, A A Janson, J E Thole.   

Abstract

The genes for two novel members (designated 85A and 85C) of the Mycobacterium leprae antigen 85 complex family of proteins and the gene for the closely related M. leprae MPT51 protein were isolated. The complete DNA sequence of the M. leprae 85C gene and partial sequences of the 85A and MPT51 genes are presented. As in M. tuberculosis, the M. leprae 85A, 85C, and previously identified 85B component genes are not closely linked on the genome. However, the MPT51 genes of both species localize close to the respective 85A component genes. Like the 85B component, the M. leprae 85A-MPT51 and 85C antigens are recognized by T cells from healthy contacts and leprosy patients.

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Year:  1993        PMID： 8359887      PMCID： PMC281059          DOI： 10.1128/iai.61.9.3642-3647.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

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  15 in total

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6.  Fibronectin-binding antigen 85 and the 10-kilodalton GroES-related heat shock protein are the predominant TH-1 response inducers in leprosy contacts.

Authors:  P Launois; M N N'Diaye; J L Cartel; I Mane; A Drowart; J P Van Vooren; J L Sarthou; K Huygen
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

7.  Heterologous expression of the Mycobacterium tuberculosis gene encoding antigen 85A in Corynebacterium glutamicum.

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