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Literature DB >> 8340762

Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.

J Buck¹, F Grün, F Derguini, Y Chen, S Kimura, N Noy, U Hämmerling.

Abstract

Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HRR) a metabolite of retinol, has been implicated as the intracellular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider S2. AR reversibly inhibits retinol- and 14-HRR-dependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intracellular signaling pathway blocked by AR in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506.

Entities: Chemical Gene Species

Mesh：

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Year: 1993 PMID： 8340762 PMCID： PMC2191109 DOI： 10.1084/jem.178.2.675

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

23 in total

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Journal: Nature Date: 1977-07-14 Impact factor: 49.962

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Journal: Biochem J Date: 1932 Impact factor: 3.857

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Authors: G Wald
Journal: Science Date: 1968-10-11 Impact factor: 47.728

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Authors: D Ong; F Chytil
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

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Authors: C Y Davis; J L Sell
Journal: J Nutr Date: 1983-10 Impact factor: 4.798

6. Cyclophilin: a specific cytosolic binding protein for cyclosporin A.

Authors: R E Handschumacher; M W Harding; J Rice; R J Drugge; D W Speicher
Journal: Science Date: 1984-11-02 Impact factor: 47.728

7. Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

Authors: S W McClean; M E Ruddel; E G Gross; J J DeGiovanna; G L Peck
Journal: Clin Chem Date: 1982-04 Impact factor: 8.327

Review 8. The steroid and thyroid hormone receptor superfamily.

Authors: R M Evans
Journal: Science Date: 1988-05-13 Impact factor: 47.728

9. TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN.

Authors: S B Wolbach; P R Howe
Journal: J Exp Med Date: 1925-11-30 Impact factor: 14.307

10. Retinoids are important cofactors in T cell activation.

Authors: A Garbe; J Buck; U Hämmerling
Journal: J Exp Med Date: 1992-07-01 Impact factor: 14.307

26 in total

1. Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.

Authors: Santiago Pérez-Rodríguez; Maria A Ortiz; Raquel Pereira; Fátima Rodríguez-Barrios; Angel R de Lera; F Javier Piedrafita
Journal: Eur J Med Chem Date: 2009-01-20 Impact factor: 6.514

2. Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.

Authors: Jianli Gong; Beatrice Hoyos; Rebeca Acin-Perez; Valerie Vinogradov; Elena Shabrova; Feng Zhao; Michael Leitges; Donald Fischman; Giovanni Manfredi; Ulrich Hammerling
Journal: FASEB J Date: 2012-05-09 Impact factor: 5.191

Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.

1. Long term culture of tumour-specific cytotoxic T cells.

2. Absorption spectra of substances derived from vitamin A.

3. Molecular basis of visual excitation.

4. Purification of cellular retinol and retinoic acid-binding proteins from rat tissue.

5. Effect of all-trans retinol and retinoic acid nutriture on the immune system of chicks.

6. Cyclophilin: a specific cytosolic binding protein for cyclosporin A.

7. Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

Review 8. The steroid and thyroid hormone receptor superfamily.

9. TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN.

10. Retinoids are important cofactors in T cell activation.

1. Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.

2. Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.

Review 3. Chemistry of the retinoid (visual) cycle.

Review 4. Retinol as electron carrier in redox signaling, a new frontier in vitamin A research.

Review 5. The mitochondrial PKCδ/retinol signal complex exerts real-time control on energy homeostasis.

Review 6. Vitamin effects on the immune system: vitamins A and D take centre stage.

7. Retinoid- and carotenoid-enriched diets influence the ontogenesis of the immune system in mice.

8. 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.

9. Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.

10. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.