Literature DB >> 6804118

Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

S W McClean, M E Ruddel, E G Gross, J J DeGiovanna, G L Peck.   

Abstract

A "high-performance" liquid-chromatographic separation of retinoids (retinol, isotretinoin, all-trans retinoic acid, retinal, etretinate, and retinyl acetate) in serum is described. The separation was used in developing a quantitative assay for retinol (vitamin A) and two therapeutic analogs, isotretinoin (13-cis-retinoic acid) and etretinate (Ro 10-9359). The procedure requires 1 mL of serum. Overall analytical recovery for retinol, isotretinoin, and etretinate from serum was 100% (SD 7%). The between-day coefficient of variation for specimens with concentrations ranging from 0.70 to 0.95 mg/L was less than 4%. Normal reference intervals for serum retinol in men and women are 0.61 to 1.33 and 0.44 to 1.19 mg/L, respectively.

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Year:  1982        PMID： 6804118

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  20 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

4.  Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells.

Authors:  M A Lane; A C Chen; S D Roman; F Derguini; L J Gudas
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

5.  4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.

Authors:  C C Achkar; F Derguini; B Blumberg; A Langston; A A Levin; J Speck; R M Evans; J Bolado; K Nakanishi; J Buck; L J Gudas
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6.  Novel retinoic acid receptor ligands in Xenopus embryos.

Authors:  B Blumberg; J Bolado; F Derguini; A G Craig; T A Moreno; D Chakravarti; R A Heyman; J Buck; R M Evans
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7.  Myeloid surface antigen abnormalities in myelodysplasia: relation to prognosis and modification by 13-cis retinoic acid.

Authors:  R E Clark; S A Smith; A Jacobs
Journal:  J Clin Pathol       Date:  1987-06       Impact factor: 3.411

8.  LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.

Authors:  Michelle A Lane; Juliana Xu; Elana W Wilen; Renia Sylvester; Fadila Derguini; Lorraine J Gudas
Journal:  Mol Cell Endocrinol       Date:  2007-10-06       Impact factor: 4.102

9.  Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.

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10.  Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene.

Authors:  J D Haag; M N Gould
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333
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