| Literature DB >> 8326318 |
L Li1, H K Wang, J J Chang, A T McPhail, D R McPhail, H Terada, T Konoshima, M Kokumai, M Kozuka, J R Estes.
Abstract
Eight cytotoxic compounds have been isolated from the CHCl3 extract of Amorpha fruticosa. One compound, 6'-O-D-beta-glucopyranosyldalpanol [10], is a new cytotoxic rotenoid. Another known rotenoid, 12 alpha beta-hydroxyamorphigenin [6], was first shown to exhibit extremely potent cytotoxicity (ED50 < 0.001 microgram/ml) in six neoplastic cell lines. In addition to these compounds, three isoflavones (afrormosin [1], 7,2',4', 5'-tetramethoxyisoflavone [2], 8-methylretusin [3]) and five rotenoids (amorphispironone [4], amorphigenin [5], dalpanol [7], 12a beta-hydroxydalpanol [8], and tephrosin [9]) were isolated. Compound 8 was isolated for the first time as a natural product from this plant. The structures of these compounds were established on the basis of spectral data; some were further confirmed by X-ray crystallographic analysis.Entities:
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Year: 1993 PMID： 8326318 DOI： 10.1021/np50095a005
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050