Literature DB >> 21424596

Base catalyzed multicomponent synthesis of spiroheterocycles with fused heterosystems.

Anand Kumar Arya1, Mahendra Kumar.   

Abstract

Structurally diverse spiroheterocycles incorporating medicinally privileged heterosystems have been synthesized by a simple and convenient synthesis involving triethylamine catalyzed multicomponent domino reaction of 2-aminobenzothiazoles with isatin and cyclic 1,3-diketones.

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Year:  2011        PMID： 21424596     DOI： 10.1007/s11030-011-9309-2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  23 in total

1.  Antitumor and antiviral activity of synthetic alpha- and beta-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides.

Authors:  Y S Sanghvi; S B Larson; S S Matsumoto; L D Nord; D F Smee; R C Willis; T L Avery; R K Robins; G R Revankar
Journal:  J Med Chem       Date:  1989-03       Impact factor: 7.446

2.  Synthesis and aldose reductase inhibitory activity of 2-substituted 6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dio nes.

Authors:  R Unno; T Yamaguchi; T Usui; T Kakigami; M Fukushima; K Mizuno; Y Baba; M Kurono
Journal:  Chem Pharm Bull (Tokyo)       Date:  1994-07       Impact factor: 1.645

3.  Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles.

Authors:  E Kashiyama; I Hutchinson; M S Chua; S F Stinson; L R Phillips; G Kaur; E A Sausville; T D Bradshaw; A D Westwell; M F Stevens
Journal:  J Med Chem       Date:  1999-10-07       Impact factor: 7.446

4.  Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.

Authors:  Bhawani Singh Rathore; M Kumar
Journal:  Bioorg Med Chem       Date:  2006-05-02       Impact factor: 3.641

5.  Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents.

Authors:  V Alagarsamy; V Raja Solomon; K Dhanabal
Journal:  Bioorg Med Chem       Date:  2006-09-30       Impact factor: 3.641

6.  Novel cyano- and amidinobenzothiazole derivatives: synthesis, antitumor evaluation, and X-ray and quantitative structure-activity relationship (QSAR) analysis.

Authors:  Irena Caleta; Marijeta Kralj; Marko Marjanović; Branimir Bertosa; Sanja Tomić; Gordana Pavlović; Kresimir Pavelić; Grace Karminski-Zamola
Journal:  J Med Chem       Date:  2009-03-26       Impact factor: 7.446

Review 7.  Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.

Authors:  Chris V Galliford; Karl A Scheidt
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

8.  Tuning of chemo- and regioselectivities in multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes.

Authors:  Valentin A Chebanov; Vyacheslav E Saraev; Sergey M Desenko; Vitaliy N Chernenko; Irina V Knyazeva; Ulrich Groth; Toma N Glasnov; C Oliver Kappe
Journal:  J Org Chem       Date:  2008-05-31       Impact factor: 4.354

Review 9.  Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography.

Authors:  Gjermund Henriksen; Behrooz H Yousefi; Alexander Drzezga; Hans-Jürgen Wester
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-03       Impact factor: 9.236

10.  A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines.

Authors:  Raju Ranjith Kumar; Subbu Perumal; Palaniappan Senthilkumar; Perumal Yogeeswari; Dharmarajan Sriram
Journal:  Eur J Med Chem       Date:  2009-05-21       Impact factor: 6.514
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  2 in total

1.  Diversity oriented one-pot three-component sequential synthesis of annulated benzothiazoloquinazolines.

Authors:  Mahendra Kumar; Kailash Sharma; Dinesh Kumar Sharma
Journal:  Org Med Chem Lett       Date:  2012-03-02

2.  Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione.

Authors:  Yan Sun; Jing Sun; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2013-01-03       Impact factor: 2.883
  2 in total

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