Literature DB >> 8300231

Regulation of Clostridium perfringens alpha-toxin-activated phospholipase C in rabbit erythrocyte membranes.

J Sakurai1, S Ochi, H Tanaka.   

Abstract

The rapid phosphatidic acid (PA) formation induced by Clostridium perfringens alpha-toxin was stimulated by AlF4- in rabbit erythrocyte membranes. GTP[gamma S] [guanosine 5'-O-(3-thiotriphosphate)] stimulated the rapid 1,2-diacylglycerol formation and inositol 1,4,5-trisphosphate release induced by the toxin. On the other hand, treatment of erythrocyte lysates with phorbol 12-myristate 13-acetate (PMA) resulted in inhibition of toxin-induced PA production, and long-term PMA or 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) treatment of the lysates led to stimulation of PA formation. Furthermore, treatment of erythrocytes with the toxin caused an increase of protein kinase C activity in membrane fractions. The results suggest that toxin-induced PA formation is mediated by endogenous phospholipase C regulated through GTP-binding protein and protein kinase C in rabbit erythrocytes.

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Year:  1994        PMID： 8300231      PMCID： PMC186165          DOI： 10.1128/iai.62.2.717-721.1994

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  35 in total

1.  Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

Authors:  T Nakamura; M Ui
Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

2.  Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.

Authors:  L F Brass; M Laposata; H S Banga; S E Rittenhouse
Journal:  J Biol Chem       Date:  1986-12-25       Impact factor: 5.157

3.  Thin-layer chromatography of the phosphoinositides.

Authors:  F Gonzalez-Sastre; J Folch-Pi
Journal:  J Lipid Res       Date:  1968-07       Impact factor: 5.922

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

Authors:  S A Orellana; P A Solski; J H Brown
Journal:  J Biol Chem       Date:  1985-05-10       Impact factor: 5.157

6.  Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

Authors:  M Volpi; P H Naccache; T F Molski; J Shefcyk; C K Huang; M L Marsh; J Munoz; E L Becker; R I Sha'afi
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

7.  Choline-linked phosphoglycerides. A source of phosphatidic acid and diglycerides in stimulated neutrophils.

Authors:  D E Agwu; L C McPhail; M C Chabot; L W Daniel; R L Wykle; C E McCall
Journal:  J Biol Chem       Date:  1989-01-25       Impact factor: 5.157

8.  Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism.

Authors:  Y Fujii; J Sakurai
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

9.  Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes.

Authors:  S Palmer; K T Hughes; D Y Lee; M J Wakelam
Journal:  Cell Signal       Date:  1989       Impact factor: 4.315

10.  Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

Authors:  J Bigay; P Deterre; C Pfister; M Chabre
Journal:  EMBO J       Date:  1987-10       Impact factor: 11.598
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  11 in total

1.  Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils.

Authors:  Masataka Oda; Syusuke Ikari; Takayuki Matsuno; Yuka Morimune; Masahiro Nagahama; Jun Sakurai
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

2.  A Method for Purification of Clostridium perfringens Phospholipase C from Recombinant Bacillus subtilis Cells.

Authors:  Y Hirata; J Minami; M Koyama; O Matsushita; S Katayama; F Jin; H Maeta; A Okabe
Journal:  Appl Environ Microbiol       Date:  1995-11       Impact factor: 4.792

3.  Site-specific mutagenesis of Clostridium perfringens alpha-toxin: replacement of Asp-56, Asp-130, or Glu-152 causes loss of enzymatic and hemolytic activities.

Authors:  M Nagahama; T Nakayama; K Michiue; J Sakurai
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

4.  Phospholipid metabolism induced by Clostridium perfringens alpha-toxin elicits a hot-cold type of hemolysis in rabbit erythrocytes.

Authors:  S Ochi; K Hashimoto; M Nagahama; J Sakurai
Journal:  Infect Immun       Date:  1996-09       Impact factor: 3.441

5.  Differences in the carboxy-terminal (Putative phospholipid binding) domains of Clostridium perfringens and Clostridium bifermentans phospholipases C influence the hemolytic and lethal properties of these enzymes.

Authors:  M Jepson; A Howells; H L Bullifent; B Bolgiano; D Crane; J Miller; J Holley; P Jayasekera; R W Titball
Journal:  Infect Immun       Date:  1999-07       Impact factor: 3.441

6.  Role of alpha-toxin in Clostridium perfringens infection determined by using recombinants of C. perfringens and Bacillus subtilis.

Authors:  M Ninomiya; O Matsushita; J Minami; H Sakamoto; M Nakano; A Okabe
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

7.  Site-directed mutagenesis of histidine residues in Clostridium perfringens alpha-toxin.

Authors:  M Nagahama; Y Okagawa; T Nakayama; E Nishioka; J Sakurai
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

8.  Clostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation.

Authors:  Teruhisa Takagishi; Masaya Takehara; Soshi Seike; Kazuaki Miyamoto; Keiko Kobayashi; Masahiro Nagahama
Journal:  Sci Rep       Date:  2017-07-12       Impact factor: 4.379

9.  Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.

Authors:  Teruhisa Takagishi; Masataka Oda; Michiko Kabura; Mie Kurosawa; Kaori Tominaga; Shiori Urano; Yoshibumi Ueda; Keiko Kobayashi; Toshihide Kobayashi; Jun Sakurai; Yutaka Terao; Masahiro Nagahama
Journal:  PLoS One       Date:  2015-04-24       Impact factor: 3.240

10.  Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NFκB activation.

Authors:  Laura Monturiol-Gross; Marietta Flores-Díaz; Maria Jose Pineda-Padilla; Ana Cristina Castro-Castro; Alberto Alape-Giron
Journal:  PLoS One       Date:  2014-01-23       Impact factor: 3.240
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