Literature DB >> 8751953

Phospholipid metabolism induced by Clostridium perfringens alpha-toxin elicits a hot-cold type of hemolysis in rabbit erythrocytes.

S Ochi1, K Hashimoto, M Nagahama, J Sakurai.   

Abstract

GTP and AIF4- significantly stimulated the late phosphatidic acid (PA) formation induced by Clostridium perfringens alpha-toxin in rabbit erythrocyte lysates. Pertussis toxin blocked the PA production. AIF4- markedly enhanced phosphatidylethanol production induced by alpha-toxin in the presence of ethanol. GTP[gamma S] stimulated the PA formation and hemolysis induced by alpha-toxin, and GDP[beta S] inhibited them. An H-to-G mutation at position 126 (H126G) induced the PA formation and hemolysis in a Co2+ concentration-dependent manner. H148G induced neither the PA formation nor hemolysis. These results suggest that the toxin-induced hemolysis is due to activation of phospholipid metabolism systems through GTP-binding protein.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8751953      PMCID： PMC174317          DOI： 10.1128/iai.64.9.3930-3933.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Characterization of phospholipase C from Pseudomonas aeruginosa as a potent inflammatory agent.

Authors:  D J Meyers; R S Berk
Journal:  Infect Immun       Date:  1990-03       Impact factor: 3.441

3.  Contraction induced by Clostridium perfringens alpha toxin in the isolated rat ileum.

Authors:  J Sakurai; Y Fujii; M Shirotani
Journal:  Toxicon       Date:  1990       Impact factor: 3.033

4.  Excitatory effect of Clostridium perfringens alpha toxin on the rat isolated aorta.

Authors:  Y Fujii; S Nomura; Y Oshita; J Sakurai
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

5.  Evidence for coupling of Clostridium perfringens alpha-toxin-induced hemolysis to stimulated phosphatidic acid formation in rabbit erythrocytes.

Authors:  J Sakurai; S Ochi; H Tanaka
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

6.  Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

Authors:  S C Olson; E P Bowman; J D Lambeth
Journal:  J Biol Chem       Date:  1991-09-15       Impact factor: 5.157

7.  Choline-linked phosphoglycerides. A source of phosphatidic acid and diglycerides in stimulated neutrophils.

Authors:  D E Agwu; L C McPhail; M C Chabot; L W Daniel; R L Wykle; C E McCall
Journal:  J Biol Chem       Date:  1989-01-25       Impact factor: 5.157

8.  Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism.

Authors:  Y Fujii; J Sakurai
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

9.  NMR studies of phospholipase C hydrolysis of phosphatidylcholine in model membranes.

Authors:  S P Bhamidipati; J A Hamilton
Journal:  J Biol Chem       Date:  1993-02-05       Impact factor: 5.157

10.  ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis.

Authors:  W J Black; J J Munoz; M G Peacock; P A Schad; J L Cowell; J J Burchall; M Lim; A Kent; L Steinman; S Falkow
Journal:  Science       Date:  1988-04-29       Impact factor: 47.728
View more
  6 in total

1.  Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils.

Authors:  Masataka Oda; Syusuke Ikari; Takayuki Matsuno; Yuka Morimune; Masahiro Nagahama; Jun Sakurai
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

2.  Site-specific mutagenesis of Clostridium perfringens alpha-toxin: replacement of Asp-56, Asp-130, or Glu-152 causes loss of enzymatic and hemolytic activities.

Authors:  M Nagahama; T Nakayama; K Michiue; J Sakurai
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

3.  Global metabolomic and lipidomic analysis reveals the potential mechanisms of hemolysis effect of Ophiopogonin D and Ophiopogonin D' in vivo.

Authors:  Huan-Hua Xu; Zhen-Hong Jiang; Cong-Shu Huang; Yu-Ting Sun; Long-Long Xu; Xiang-Ling Tang; Hong-Ling Tan; Zeng-Chun Ma; Yue Gao
Journal:  Chin Med       Date:  2021-01-06       Impact factor: 5.455

Review 4.  Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase.

Authors:  Laura Monturiol-Gross; Fabian Villalta-Romero; Marietta Flores-Díaz; Alberto Alape-Girón
Journal:  FEBS Open Bio       Date:  2021-11-08       Impact factor: 2.693

5.  Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.

Authors:  Teruhisa Takagishi; Masataka Oda; Michiko Kabura; Mie Kurosawa; Kaori Tominaga; Shiori Urano; Yoshibumi Ueda; Keiko Kobayashi; Toshihide Kobayashi; Jun Sakurai; Yutaka Terao; Masahiro Nagahama
Journal:  PLoS One       Date:  2015-04-24       Impact factor: 3.240

Review 6.  Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.

Authors:  Masataka Oda; Yutaka Terao; Jun Sakurai; Masahiro Nagahama
Journal:  Toxins (Basel)       Date:  2015-12-03       Impact factor: 4.546
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.