Literature DB >> 8291609

The LEC rat: a model for human hepatitis, liver cancer, and much more.

M Mori1, A Hattori, M Sawaki, N Tsuzuki, N Sawada, M Oyamada, N Sugawara, K Enomoto.   

Abstract

The LEC rat is an inbred mutant strain with spontaneous hepatitis isolated from Long-Evans rats. Since approximately 40% of LEC rats die of fulminant hepatitis, the rat serves an animal model for studying the pathogenesis and treatment of human fulminant hepatitis. The remaining 60% of LEC rats survive and develop chronic (prolonged) hepatitis and subsequently develop liver cancer. Therefore, the LEC rat serves an important animal model for studying the significance of chronic hepatitis in the development of human liver cancer, which often develops in association with chronic hepatitis. The LEC rat can also be used as an animal model of Wilson's disease, since recent studies have disclosed high copper accumulation in the liver and low ceruloplasmin concentration in the serum of this mutant rat.

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Year:  1994        PMID： 8291609      PMCID： PMC1887108     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  15 in total

Review 1.  A new rat model for the study of hepatocarcinogenesis.

Authors:  K Enomoto; H Takahashi; M Mori
Journal:  J Gastroenterol Hepatol       Date:  1992 Jan-Feb       Impact factor: 4.029

2.  High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine.

Authors:  H Takahashi; K Enomoto; Y Nakajima; M Mori
Journal:  Cancer Lett       Date:  1990-06-15       Impact factor: 8.679

3.  Possible involvement of c-myc but not ras genes in hepatocellular carcinomas developing after spontaneous hepatitis in LEC rats.

Authors:  Y Fujimoto; Y Ishizaka; T Tahira; H Sone; H Takahashi; K Enomoto; M Mori; T Sugimura; M Nagao
Journal:  Mol Carcinog       Date:  1991       Impact factor: 4.784

4.  Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease.

Authors:  Y Li; Y Togashi; S Sato; T Emoto; J H Kang; N Takeichi; H Kobayashi; Y Kojima; Y Une; J Uchino
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

5.  Copper metabolism in the LEC rat: involvement of induction of metallothionein and disposition of zinc and iron.

Authors:  N Sugawara; C Sugawara; M Katakura; H Takahashi; M Mori
Journal:  Experientia       Date:  1991-10-15

6.  Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans cinnamon mutant rat.

Authors:  T Yamada; T Agui; Y Suzuki; M Sato; K Matsumoto
Journal:  J Biol Chem       Date:  1993-04-25       Impact factor: 5.157

7.  Harmful effect of administration of copper on LEC rats.

Authors:  N Sugawara; C Sugawara; M Katakura; H Takahashi; M Mori
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1991-09

8.  Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats.

Authors:  H Sone; M Maeda; M Gotoh; K Wakabayashi; T Ono; M C Yoshida; N Takeichi; M Mori; S Hirohashi; T Sugimura
Journal:  Mol Carcinog       Date:  1992       Impact factor: 4.784

9.  Accumulation of abnormally high ploid nuclei in the liver of LEC rats developing spontaneous hepatitis.

Authors:  Y Fujimoto; M Oyamada; A Hattori; H Takahashi; M Sawaki; K Dempo; M Mori; M Nagao
Journal:  Jpn J Cancer Res       Date:  1989-01

10.  Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer.

Authors:  T Ono; S Abe; M C Yoshida
Journal:  Jpn J Cancer Res       Date:  1991-05
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  15 in total

1.  Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice.

Authors:  Dominik Huster; Milton J Finegold; Clinton T Morgan; Jason L Burkhead; Randal Nixon; Scott M Vanderwerf; Conrad T Gilliam; Svetlana Lutsenko
Journal:  Am J Pathol       Date:  2006-02       Impact factor: 4.307

2.  Metallothionein-1 and metallothionein-2 gene expression and localisation of apoptotic cells in Zn-treated LEC rat liver.

Authors:  Alessandro Santon; Giacomo Carlo Sturniolo; Vincenzo Albergoni; Paola Irato
Journal:  Histochem Cell Biol       Date:  2003-04-08       Impact factor: 4.304

3.  Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century.

Authors:  Mario Manto; Daniele Marmolino
Journal:  Cerebellum       Date:  2009-09       Impact factor: 3.847

4.  Contribution of Va24Vb11 natural killer T cells in Wilsonian hepatitis.

Authors:  M Kinebuchi; A Matsuura; K Ohya; W Abo; J Kitazawa
Journal:  Clin Exp Immunol       Date:  2005-01       Impact factor: 4.330

5.  Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method.

Authors:  Jin Wang; Bifeng Yuan; Candace Guerrero; Ralf Bahde; Sanjeev Gupta; Yinsheng Wang
Journal:  Anal Chem       Date:  2011-02-16       Impact factor: 6.986

6.  Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats.

Authors:  Dong Woon Kim; Tae-Beom Ahn; Jong Min Kim; Gye Sun Jeon; Je Hoon Seo; Beom S Jeon; Sa Sun Cho
Journal:  Neurochem Res       Date:  2005-04       Impact factor: 3.996

7.  High levels of E4-PHA-reactive oligosaccharides: potential as marker for cells with characteristics of hepatic progenitor cells.

Authors:  Nozomi Sasaki; Kenta Moriwaki; Naofumi Uozumi; Katsuhisa Noda; Naoyuki Taniguchi; Akihiko Kameyama; Hisashi Narimatsu; Shunsaku Takeishi; Masao Yamada; Nobuto Koyama; Eiji Miyoshi
Journal:  Glycoconj J       Date:  2009-12       Impact factor: 2.916

8.  Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis.

Authors:  Zhaohui Feng; Wenwei Hu; Moon-Shong Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-08       Impact factor: 11.205

Review 9.  Application of genome editing technologies in rats for human disease models.

Authors:  Kazuto Yoshimi; Tomoji Mashimo
Journal:  J Hum Genet       Date:  2017-11-20       Impact factor: 3.172

10.  Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion.

Authors:  Jin Wang; Huachuan Cao; Changjun You; Bifeng Yuan; Ralf Bahde; Sanjeev Gupta; Chikako Nishigori; Laura J Niedernhofer; Philip J Brooks; Yinsheng Wang
Journal:  Nucleic Acids Res       Date:  2012-05-11       Impact factor: 16.971
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