Literature DB >> 16076018

Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats.

Dong Woon Kim1, Tae-Beom Ahn, Jong Min Kim, Gye Sun Jeon, Je Hoon Seo, Beom S Jeon, Sa Sun Cho.   

Abstract

The abundance of cellular superoxide dismutase (Mn-SOD) was examined immunocytochemically in different regions of the brain of Long-Evans Cinnamon (LEC) rats at 4 and 50 weeks of age. When all animals develop chronic hepatitis, the substantia nigra and striatum showed a marked increase in Mn-SOD immunoreactivity versus Long-Evans agouti (LEA) rats of the same age. Mn-SOD was localized predominantly in dopaminergic neurons. The elevation of Mn-SOD level in the dopaminergic neurons of LEC rats may reflect the oxidative stress caused by copper accumulation in this brain area. Our data suggest that LEC rats may contribute to the mechanistic study of neurological manifestations in nigro-striatal dopaminergic system of Wilson's disease.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16076018     DOI： 10.1007/s11064-005-2683-3

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  14 in total

1.  The Long-Evans Cinnamon rat: an animal model for Wilson's disease.

Authors:  K Terada; T Sugiyama
Journal:  Pediatr Int       Date:  1999-08       Impact factor: 1.524

Review 2.  Wilson's disease: the scourge of copper.

Authors:  N Gitlin
Journal:  J Hepatol       Date:  1998-04       Impact factor: 25.083

Review 3.  Metal-induced hepatotoxicity.

Authors:  R S Britton
Journal:  Semin Liver Dis       Date:  1996-02       Impact factor: 6.115

4.  Localization of the Wilson's disease protein product to mitochondria.

Authors:  S Lutsenko; M J Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

5.  Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease.

Authors:  Henryk Barthel; Wieland Hermann; Regine Kluge; Swen Hesse; David R Collingridge; Armin Wagner; Osama Sabri
Journal:  AJNR Am J Neuroradiol       Date:  2003-02       Impact factor: 3.825

6.  The LEC rat: a model for human hepatitis, liver cancer, and much more.

Authors:  M Mori; A Hattori; M Sawaki; N Tsuzuki; N Sawada; M Oyamada; N Sugawara; K Enomoto
Journal:  Am J Pathol       Date:  1994-01       Impact factor: 4.307

7.  Cofactors of mitochondrial enzymes attenuate copper-induced death in vitro and in vivo.

Authors:  Christian T Sheline; Eric H Choi; Jeong-Sook Kim-Han; Laura L Dugan; Dennis W Choi
Journal:  Ann Neurol       Date:  2002-08       Impact factor: 10.422

8.  Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis.

Authors:  R J Sokol; D Twedt; J M McKim; M W Devereaux; F M Karrer; I Kam; G von Steigman; M R Narkewicz; B R Bacon; R S Britton
Journal:  Gastroenterology       Date:  1994-12       Impact factor: 22.682

9.  The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene.

Authors:  J Wu; J R Forbes; H S Chen; D W Cox
Journal:  Nat Genet       Date:  1994-08       Impact factor: 38.330

10.  Dopamine transporter imaging with [123I]-beta-CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease.

Authors:  B Jeon; J M Kim; J M Jeong; K M Kim; Y S Chang; D S Lee; M C Lee
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-07       Impact factor: 10.154
View more
  1 in total

Review 1.  Animal models of Wilson disease.

Authors:  Emily Reed; Svetlana Lutsenko; Oliver Bandmann
Journal:  J Neurochem       Date:  2018-06-26       Impact factor: 5.372
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.