Literature DB >> 1936203

Copper metabolism in the LEC rat: involvement of induction of metallothionein and disposition of zinc and iron.

N Sugawara1, C Sugawara, M Katakura, H Takahashi, M Mori.   

Abstract

The Cu concentration was about 40 times higher in the liver of LEC (Long-Evans with a cinnamon-like coat color) rats aged 77 days (227.5 +/- 21.6 micrograms/g liver) than in Fischer rats (5.2 +/- 0.1 microgram/g liver). However, in the kidney and brain of the LEC rats, Cu concentrations were lower than in these organs of the Fischer rats. Cu concentration in the hepatic metallothionein fraction was about 130 times higher in the LEC rats than in the Fischer rats. The LEC rats showed markedly low concentrations of Cu in the serum and bile. It seems likely that excretion of Cu from the liver into the bile and blood (as ceruloplasmin) is inherently lacking in the LEC rat.

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Year:  1991        PMID： 1936203     DOI： 10.1007/bf01923342

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  The Cd-Chelex assay: a new sensitive method to determine metallothionein containing zinc and cadmium.

Authors:  R Bartsch; D Klein; K H Summer
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

Review 2.  Copper homeostasis in the mammalian system.

Authors:  G W Evans
Journal:  Physiol Rev       Date:  1973-07       Impact factor: 37.312

3.  Age-dependent alterations in hepatic subcellular copper distribution and plasma ceruloplasmin.

Authors:  G W Evans; D R Myron; N F Cornatzer; W E Cornatzer
Journal:  Am J Physiol       Date:  1970-01

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Authors:  A Sass-Kortsak
Journal:  Adv Clin Chem       Date:  1965       Impact factor: 5.394

5.  Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride.

Authors:  K H Schosinsky; H P Lehmann; M F Beeler
Journal:  Clin Chem       Date:  1974-12       Impact factor: 8.327

6.  The nature of the copper complexes in bile and their relationship to the absorption and excretion of copper in normal subjects and in Wilson's disease.

Authors:  K O Lewis
Journal:  Gut       Date:  1973-03       Impact factor: 23.059

7.  New mutation causing hereditary hepatitis in the laboratory rat.

Authors:  M C Yoshida; R Masuda; M Sasaki; N Takeichi; H Kobayashi; K Dempo; M Mori
Journal:  J Hered       Date:  1987 Nov-Dec       Impact factor: 2.645

8.  Induction and degradation of copper-induced metallothioneins in rat liver as studied at isometallothionein levels.

Authors:  K T Suzuki; M Yamamura
Journal:  Toxicol Lett       Date:  1980-09       Impact factor: 4.372

9.  Relationship between ceruloplasmin and Cu status involving metallothionein induced by several heavy metals in the mouse.

Authors:  N Sugawara; C Sugawara
Journal:  Arch Toxicol       Date:  1987-04       Impact factor: 5.153

10.  Effects of subcutaneous and oral cadmium on iron metabolism: role of ceruloplasmin and metallothionein.

Authors:  N Sugawara; C Sugawara; H Miyake
Journal:  Arch Toxicol       Date:  1984-11       Impact factor: 5.153
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  6 in total

Review 1.  Animal models of Wilson disease.

Authors:  Emily Reed; Svetlana Lutsenko; Oliver Bandmann
Journal:  J Neurochem       Date:  2018-06-26       Impact factor: 5.372

2.  The LEC rat: a model for human hepatitis, liver cancer, and much more.

Authors:  M Mori; A Hattori; M Sawaki; N Tsuzuki; N Sawada; M Oyamada; N Sugawara; K Enomoto
Journal:  Am J Pathol       Date:  1994-01       Impact factor: 4.307

3.  Biliary excretion of exogenous cadmium and manganese in Long-Evans Cinnamon (LEC) rats characterized by an inherently gross amount of copper-metallothionein in the liver.

Authors:  N Sugawara; D Li; C Sugawara
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

4.  A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation.

Authors:  J Koropatnick; M G Cherian
Journal:  Biochem J       Date:  1993-12-01       Impact factor: 3.857

5.  Biliary excretion of copper in Fischer rats treated with copper salt and in Long-Evans cinnamon (LEC) rats with an inherently abnormal copper metabolism.

Authors:  N Sugawara; D Li; M Katakura; C Sugawara
Journal:  Biol Trace Elem Res       Date:  1994 Oct-Nov       Impact factor: 3.738

6.  Gene expression patterns in the progression of canine copper-associated chronic hepatitis.

Authors:  Karen Dirksen; Bart Spee; Louis C Penning; Ted S G A M van den Ingh; Iwan A Burgener; Adrian L Watson; Marian Groot Koerkamp; Jan Rothuizen; Frank G van Steenbeek; Hille Fieten
Journal:  PLoS One       Date:  2017-05-01       Impact factor: 3.240
  6 in total

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