| Literature DB >> 8287967 |
R A Crowther1, O F Olesen, M J Smith, R Jakes, M Goedert.
Abstract
The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tau protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.Entities:
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Year: 1994 PMID： 8287967 DOI： 10.1016/0014-5793(94)80260-2
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124