| Literature DB >> 9626057 |
M Pérez1, J M Valpuesta, E M de Garcini, C Quintana, M Arrasate, J L López Carrascosa, A Rábano, J García de Yébenes, J Avila.
Abstract
Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.Entities:
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Year: 1998 PMID： 9626057 PMCID： PMC1858430
Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307