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Literature DB >> 23527380

Molecular insights into the reversible formation of tau protein fibrils.

Yin Luo¹, Paul Dinkel, Xiang Yu, Martin Margittai, Jie Zheng, Ruth Nussinov, Guanghong Wei, Buyong Ma.

Abstract

We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation of tau fibrils.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2013 PMID： 23527380 PMCID： PMC3637047 DOI： 10.1039/c3cc00241a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

21 in total

1. Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.

Authors: Jozef Adamcik; Cecile Lara; Ivan Usov; Jae Sun Jeong; Francesco S Ruggeri; Giovanni Dietler; Hilal A Lashuel; Ian W Hamley; Raffaele Mezzenga
Journal: Nanoscale Date: 2012-06-11 Impact factor: 7.790

Review 2. Alzheimer's disease: the amyloid cascade hypothesis.

Authors: J A Hardy; G A Higgins
Journal: Science Date: 1992-04-10 Impact factor: 47.728

3. Intrinsic thermal expansivity and hydrational properties of amyloid peptide Abeta42 in liquid water.

Authors: I Brovchenko; R R Burri; A Krukau; A Oleinikova; R Winter
Journal: J Chem Phys Date: 2008-11-21 Impact factor: 3.488

4. Dissociation of amyloid fibrils of alpha-synuclein in supercooled water.

Authors: Hai-Young Kim; Min-Kyu Cho; Dietmar Riedel; Claudio O Fernandez; Markus Zweckstetter
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

5. Variations in filament conformation dictate seeding barrier between three- and four-repeat tau.

Authors: Paul D Dinkel; Ayisha Siddiqua; Huy Huynh; Monil Shah; Martin Margittai
Journal: Biochemistry Date: 2011-05-02 Impact factor: 3.162

6. Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering.

Authors: Alexander V Shkumatov; Subashchandrabose Chinnathambi; Eckhard Mandelkow; Dmitri I Svergun
Journal: Proteins Date: 2011-05-10

7. Oligomers of the prion protein fragment 106-126 are likely assembled from beta-hairpins in solution, and methionine oxidation inhibits assembly without altering the peptide's monomeric conformation.

Authors: Megan Grabenauer; Chun Wu; Patricia Soto; Joan-Emma Shea; Michael T Bowers
Journal: J Am Chem Soc Date: 2010-01-20 Impact factor: 15.419

8. Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution.

Authors: Valéry Ozenne; Robert Schneider; Mingxi Yao; Jie-rong Huang; Loïc Salmon; Markus Zweckstetter; Malene Ringkjøbing Jensen; Martin Blackledge
Journal: J Am Chem Soc Date: 2012-08-28 Impact factor: 15.419

9. The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

Authors: Sadasivam Jeganathan; Martin von Bergen; Eva-Maria Mandelkow; Eckhard Mandelkow
Journal: Biochemistry Date: 2008-09-11 Impact factor: 3.162

10. Structural characterization of the core of the paired helical filament of Alzheimer disease.

Authors: C M Wischik; M Novak; P C Edwards; A Klug; W Tichelaar; R A Crowther
Journal: Proc Natl Acad Sci U S A Date: 1988-07 Impact factor: 11.205

14 in total

Review 1. Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.

Authors: Hyunbum Jang; Fernando Teran Arce; Srinivasan Ramachandran; Bruce L Kagan; Ratnesh Lal; Ruth Nussinov
Journal: Chem Soc Rev Date: 2014-10-07 Impact factor: 54.564

Review 2. Amyloidogenesis of Tau protein.

Authors: Bartosz Nizynski; Wojciech Dzwolak; Krzysztof Nieznanski
Journal: Protein Sci Date: 2017-09-13 Impact factor: 6.725

3. How Does Hyperphopsphorylation Promote Tau Aggregation and Modulate Filament Structure and Stability?

Authors: Liang Xu; Jie Zheng; Martin Margittai; Ruth Nussinov; Buyong Ma
Journal: ACS Chem Neurosci Date: 2016-02-24 Impact factor: 4.418

4. A Protocol for the Design of Protein and Peptide Nanostructure Self-Assemblies Exploiting Synthetic Amino Acids.

Authors: Nurit Haspel; Jie Zheng; Carlos Aleman; David Zanuy; Ruth Nussinov
Journal: Methods Mol Biol Date: 2017

5. The distinct structural preferences of tau protein repeat domains.

Authors: Xuhua Li; Xuewei Dong; Guanghong Wei; Martin Margittai; Ruth Nussinov; Buyong Ma
Journal: Chem Commun (Camb) Date: 2018-05-31 Impact factor: 6.222

6. Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal.

Authors: Liang Xu; Ruth Nussinov; Buyong Ma
Journal: Chem Commun (Camb) Date: 2015-12-15 Impact factor: 6.222

Review 7. Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Authors: Phuong H Nguyen; Ayyalusamy Ramamoorthy; Bikash R Sahoo; Jie Zheng; Peter Faller; John E Straub; Laura Dominguez; Joan-Emma Shea; Nikolay V Dokholyan; Alfonso De Simone; Buyong Ma; Ruth Nussinov; Saeed Najafi; Son Tung Ngo; Antoine Loquet; Mara Chiricotto; Pritam Ganguly; James McCarty; Mai Suan Li; Carol Hall; Yiming Wang; Yifat Miller; Simone Melchionna; Birgit Habenstein; Stepan Timr; Jiaxing Chen; Brianna Hnath; Birgit Strodel; Rakez Kayed; Sylvain Lesné; Guanghong Wei; Fabio Sterpone; Andrew J Doig; Philippe Derreumaux
Journal: Chem Rev Date: 2021-02-05 Impact factor: 60.622