Literature DB >> 8285640

Reduced susceptibilities of Shigella sonnei strains isolated from patients with dysentery to fluoroquinolones.

S Horiuchi1, Y Inagaki, N Yamamoto, N Okamura, Y Imagawa, R Nakaya.   

Abstract

Seven clinical isolates of Shigella sonnei with reduced susceptibilities to fluoroquinolones (sparfloxacin, ciprofloxacin, and ofloxacin) were obtained. The MICs of fluoroquinolones against these S. sonnei strains were 16 to 32 times higher than those obtained against typical strains that are highly susceptible to these agents. The kinetics of [14C]ofloxacin accumulation in these clinical strains were not different from those in the fully susceptible strains. However, DNA synthesis was much less inhibited by ofloxacin in the strains with reduced susceptibility. Analysis of the in vitro activity of the partially purified DNA gyrase from these isolates showed that the decreased quinolone susceptibility of the S. sonnei strains was likely due to mutation of the DNA gyrase subunit A gene.

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Year:  1993        PMID： 8285640      PMCID： PMC192415          DOI： 10.1128/AAC.37.11.2486

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  Mechanisms of quinolone resistance in a clinical isolate of Escherichia coli highly resistant to fluoroquinolones but susceptible to nalidixic acid.

Authors:  N Moniot-Ville; J Guibert; N Moreau; J F Acar; E Collatz; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

2.  DNA gyrase: an enzyme that introduces superhelical turns into DNA.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; H A Nash
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

3.  The intrinsic ATPase of DNA gyrase.

Authors:  A Sugino; N R Cozzarelli
Journal:  J Biol Chem       Date:  1980-07-10       Impact factor: 5.157

4.  Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes.

Authors:  L L Shen; W E Kohlbrenner; D Weigl; J Baranowski
Journal:  J Biol Chem       Date:  1989-02-15       Impact factor: 5.157

5.  In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea.

Authors:  J Segreti; J A Nelson; L J Goodman; R L Kaplan; G M Trenholme
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

6.  Antimicrobial resistance of Shigella isolates in Bangladesh, 1983-1990: increasing frequency of strains multiply resistant to ampicillin, trimethoprim-sulfamethoxazole, and nalidixic acid.

Authors:  M L Bennish; M A Salam; M A Hossain; J Myaux; E H Khan; J Chakraborty; F Henry; C Ronsmans
Journal:  Clin Infect Dis       Date:  1992-05       Impact factor: 9.079

7.  Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.

Authors:  H Yoshida; M Bogaki; M Nakamura; L M Yamanaka; S Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1991-08       Impact factor: 5.191

8.  DNA gyrase: subunit structure and ATPase activity of the purified enzyme.

Authors:  K Mizuuchi; M H O'Dea; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

9.  Transduction of R factors by a Proteus mirabilis bacteriophage.

Authors:  R Nakaya; R Rownd
Journal:  J Bacteriol       Date:  1971-06       Impact factor: 3.490

10.  Mechanisms of quinolone resistance in Escherichia coli: characterization of nfxB and cfxB, two mutant resistance loci decreasing norfloxacin accumulation.

Authors:  D C Hooper; J S Wolfson; K S Souza; E Y Ng; G L McHugh; M N Swartz
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191
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Authors:  Sharon M Erdman; Elizabeth E Buckner; Janet F Hindler
Journal:  J Pediatr Pharmacol Ther       Date:  2008-01

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Authors:  Y W Chu; E T Houang; D J Lyon; J M Ling; T K Ng; A F Cheng
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

Review 5.  Sparfloxacin. A review of its antibacterial activity, pharmacokinetic properties, clinical efficacy and tolerability in lower respiratory tract infections.

Authors:  K L Goa; H M Bryson; A Markham
Journal:  Drugs       Date:  1997-04       Impact factor: 9.546

6.  Efficacy of Ciprofloxacin for Treatment of Cholera Associated with Diminished Susceptibility to Ciprofloxacin to Vibrio cholerae O1.

Authors:  Wasif Ali Khan; Debasish Saha; Sabeena Ahmed; Mohammed Abdus Salam; Michael Louis Bennish
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7.  Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015.

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8.  South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study.

Authors:  Hao Chung The; Maia A Rabaa; Duy Pham Thanh; Niall De Lappe; Martin Cormican; Mary Valcanis; Benjamin P Howden; Sonam Wangchuk; Ladaporn Bodhidatta; Carl J Mason; To Nguyen Thi Nguyen; Duong Vu Thuy; Corinne N Thompson; Nguyen Phu Huong Lan; Phat Voong Vinh; Tuyen Ha Thanh; Paul Turner; Poda Sar; Guy Thwaites; Nicholas R Thomson; Kathryn E Holt; Stephen Baker
Journal:  PLoS Med       Date:  2016-08-02       Impact factor: 11.069

9.  Introduction and establishment of fluoroquinolone-resistant Shigella sonnei into Bhutan.

Authors:  Hao Chung The; Maia A Rabaa; Duy Pham Thanh; Sirigade Ruekit; Sonam Wangchuk; Tshering Dorji; Kinzang Pem Tshering; To Nguyen Thi Nguyen; Phat Voong Vinh; Tuyen Ha Thanh; Chau Nguyen Ngoc Minh; Paul Turner; Poda Sar; Guy Thwaites; Kathryn E Holt; Nicholas R Thomson; Ladaporn Bodhidatta; Carl Jeffries Mason; Stephen Baker
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  9 in total

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