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Literature DB >> 8268656

Characterization and mapping of the human SOX4 gene.

C J Farr¹, D J Easty, J Ragoussis, J Collignon, R Lovell-Badge, P N Goodfellow.

Abstract

The SOX genes comprise a large family related by homology to the HMG-box region of the testis-determining gene SRY. We have cloned and sequenced the human SOX4 gene. The open reading frame encodes a 474 amino acid protein, which includes an HMG-box. The non-box sequence is particularly rich in serine residues and has several polyglycine and polyalanine stretches. With somatic cell hybrids, human SOX4 has been mapped to Chromosome (Chr) 6p distal to the MHC region. There is no evidence for clustering of other members of the SOX1, -2, and -3 or SOX4 gene families around the SOX4 locus.

Entities: Chemical

Mesh：

Substances：

Year: 1993 PMID： 8268656 DOI： 10.1007/BF00361388

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

38 in total

1. Hidden messages in genetic maps.

Authors: C J Farr; P N Goodfellow
Journal: Science Date: 1992-10-02 Impact factor: 47.728

2. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures.

Authors: K Giese; J Cox; R Grosschedl
Journal: Cell Date: 1992-04-03 Impact factor: 41.582

Review 3. Identification of a core motif that is recognized by three members of the HMG class of transcriptional regulators: IRE-ABP, SRY, and TCF-1 alpha.

Authors: M Alexander-Bridges; L Ercolani; X F Kong; N Nasrin
Journal: J Cell Biochem Date: 1992-02 Impact factor: 4.429

4. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors: H Aviv; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1972-06 Impact factor: 11.205

5. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.

Authors: H M Jantzen; A Admon; S P Bell; R Tjian
Journal: Nature Date: 1990-04-26 Impact factor: 49.962

6. Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.

Authors: E J Ormerod; C A Everett; I R Hart
Journal: Cancer Res Date: 1986-02 Impact factor: 12.701

7. Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias.

Authors: L Nagarajan; E Louie; Y Tsujimoto; A ar-Rushdi; K Huebner; C M Croce
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

8. Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

Authors: C Q Lee; Y D Yun; J P Hoeffler; J F Habener
Journal: EMBO J Date: 1990-12 Impact factor: 11.598

9. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

Authors: J Gubbay; J Collignon; P Koopman; B Capel; A Economou; A Münsterberg; N Vivian; P Goodfellow; R Lovell-Badge
Journal: Nature Date: 1990-07-19 Impact factor: 49.962

10. Clonal separation of mature melanocytes from premelanocytes in a diploid human cell strain: spontaneous and induced pigmentation of premelanocytes.

Authors: D C Bennett; K Bridges; I A McKay
Journal: J Cell Sci Date: 1985-08 Impact factor: 5.285

11 in total

10. SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.

Authors: R Sun; B Jiang; H Qi; X Zhang; J Yang; J Duan; Y Li; G Li
Journal: Cell Death Dis Date: 2015-11-19 Impact factor: 8.469

Characterization and mapping of the human SOX4 gene.

1. Hidden messages in genetic maps.

2. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures.

Review 3. Identification of a core motif that is recognized by three members of the HMG class of transcriptional regulators: IRE-ABP, SRY, and TCF-1 alpha.

4. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

5. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.

6. Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.

7. Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias.

8. Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

9. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

10. Clonal separation of mature melanocytes from premelanocytes in a diploid human cell strain: spontaneous and induced pigmentation of premelanocytes.

1. Prognostic significance of Sox4 expression in human cutaneous melanoma and its role in cell migration and invasion.

Review 2. Expression profiling of human breast cancers and gene regulation by progesterone receptors.

Review 3. SOX genes: architects of development.

4. Balanced autosomal translocations and ovarian dysgenesis.

5. Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway.

6. A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk.

Review 7. Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis.

8. The cDNA sequence and chromosomal location of the human SOX2 gene.

9. Distribution of estrogen and progesterone receptors isoforms in endometrial cancer.

10. SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.