Literature DB >> 2374589

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

J Gubbay1, J Collignon, P Koopman, B Capel, A Economou, A Münsterberg, N Vivian, P Goodfellow, R Lovell-Badge.   

Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

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Year:  1990        PMID： 2374589     DOI： 10.1038/346245a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  420 in total

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