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Literature DB >> 23080209

Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis.

Seyed Mehdi Jafarnejad¹, Gholamreza Safaee Ardekani, Mazyar Ghaffari, Gang Li.

Abstract

In addition to their critical roles in embryonic development, cell fate decision, and differentiation, members of Sox (Sry-related high-mobility group box) family of transcription factors including Sox4 have been implicated in various cancers. Multiple studies have revealed an increased expression along with specific oncogenic function of Sox4 in tumors, while others observed a reduced expression of Sox4 in different types of malignancies and suppression of tumor initiation or progression by this protein. More interestingly, the prognostic value of Sox4 is debated due to obvious differences between various reports as well as inconsistencies within specific studies. This review summarizes our current understanding of Sox4 expression pattern and its transcription-dependent, as well as transcription-independent, functions in tumor initiation or progression and its correlation with patient survival. We also discuss the existing discrepancies between different reports and their possible explanations.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23080209 DOI： 10.1007/s00018-012-1187-y

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

133 in total

1. The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.

Authors: Zhengliang Gao; Kerstin Ure; Peiguo Ding; Mostafa Nashaat; Laura Yuan; Jing Ma; Robert E Hammer; Jenny Hsieh
Journal: J Neurosci Date: 2011-06-29 Impact factor: 6.167

2. Changes in nuclear proteins on transformation of rat epithelial thyroid cells by a murine sarcoma retrovirus.

Authors: V Giancotti; M T Berlingieri; P P DiFiore; A Fusco; G Vecchio; C Crane-Robinson
Journal: Cancer Res Date: 1985-12 Impact factor: 12.701

3. Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors.

Authors: Tim Reichling; Kathleen Heppner Goss; Daniel J Carson; Robert W Holdcraft; Cathy Ley-Ebert; Dave Witte; Bruce J Aronow; Joanna Groden
Journal: Cancer Res Date: 2005-01-01 Impact factor: 12.701

4. Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma.

Authors: Gunhild M Maelandsmo; Ruth Holm; Jahn M Nesland; Øystein Fodstad; Vivi Ann Flørenes
Journal: Clin Cancer Res Date: 2003-08-15 Impact factor: 12.531

5. Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma.

Authors: Henry F Frierson; Adel K El-Naggar; John B Welsh; Lisa M Sapinoso; Andrew I Su; Jun Cheng; Takashi Saku; Christopher A Moskaluk; Garret M Hampton
Journal: Am J Pathol Date: 2002-10 Impact factor: 4.307

6. SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells.

Authors: Yu-Heng Lai; Jessica Cheng; Dongmei Cheng; Mattie E Feasel; Kyle D Beste; Junmin Peng; Asma Nusrat; Carlos S Moreno
Journal: BMC Cell Biol Date: 2011-11-19 Impact factor: 4.241

7. Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

Authors: C J J Boogerd; L Y E Wong; M van den Boogaard; M L Bakker; F Tessadori; J Bakkers; P A C 't Hoen; A F Moorman; V M Christoffels; P Barnett
Journal: Cell Mol Life Sci Date: 2011-05-03 Impact factor: 9.261

8. Regulation of p53 stability and apoptosis by a ROR agonist.

Authors: Yongjun Wang; Laura A Solt; Douglas J Kojetin; Thomas P Burris
Journal: PLoS One Date: 2012-04-11 Impact factor: 3.240

9. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties.

Authors: Peter Dy; Alfredo Penzo-Méndez; Hongzhe Wang; Carlos E Pedraza; Wendy B Macklin; Véronique Lefebvre
Journal: Nucleic Acids Res Date: 2008-04-10 Impact factor: 16.971

10. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.

Authors: C L Andersen; L L Christensen; K Thorsen; T Schepeler; F B Sørensen; H W Verspaget; R Simon; M Kruhøffer; L A Aaltonen; S Laurberg; T F Ørntoft
Journal: Br J Cancer Date: 2009-01-20 Impact factor: 7.640

20 in total

1. Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR.

Authors: Lei Zhang; Shuo Chen; Nirong Bao; Chao Yang; Yunfan Ti; Liwu Zhou; Jianning Zhao
Journal: J Mol Histol Date: 2015-10-29 Impact factor: 2.611

2. Increased expression of SOX4 is associated with colorectal cancer progression.

Authors: Baochun Wang; Yixiong Li; Fengbo Tan; Zhanxiang Xiao
Journal: Tumour Biol Date: 2016-01-14

3. Increased expression of SOX4 is a biomarker for malignant status and poor prognosis in patients with non-small cell lung cancer.

Authors: Dingmiao Wang; Ting Hao; Yang Pan; Xiaowei Qian; Daixing Zhou
Journal: Mol Cell Biochem Date: 2015-01-08 Impact factor: 3.396

Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis.

1. The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.

2. Changes in nuclear proteins on transformation of rat epithelial thyroid cells by a murine sarcoma retrovirus.

3. Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors.

4. Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma.

5. Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma.

6. SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells.

7. Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

8. Regulation of p53 stability and apoptosis by a ROR agonist.

9. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties.

10. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.

1. Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR.

2. Increased expression of SOX4 is associated with colorectal cancer progression.

3. Increased expression of SOX4 is a biomarker for malignant status and poor prognosis in patients with non-small cell lung cancer.

4. Over-expression of Sox4 and β-catenin is associated with a less favorable prognosis of osteosarcoma.

5. SOX4 overexpression is a novel biomarker of malignant status and poor prognosis in breast cancer patients.

6. Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer.

7. Association of SOX4 regulated by tumor suppressor miR-30a with poor prognosis in low-grade chondrosarcoma.

Review 8. SOX4 is a potential prognostic factor in human cancers: a systematic review and meta-analysis.

9. Epigenetic regulation of Sox4 during palate development.

Review 10. SOXC Genes and the Control of Skeletogenesis.