| Literature DB >> 825607 |
A E Postlethwaite, R Snyderman, A H Kang.
Abstract
A quantitative assay that measures fibroblast chemotaxis in vitro is described. Application of this technique has revealed that peripheral blood lymphocytes stimulated by antigen or mitogen in vitro produce a factor that is chemotactic for human dermal fibroblasts. This lymphocyte-derived chemotactic factor for fibroblasts (LDCF-F) is different from the lymphokine that is chemotactic for monocytes or macrophages. Macrophages are required for the generation of LDCF-F by T lymphocytes stimulated by phytohemagglutinin. The fibroblast chemotactic factor is heat stable (56 degrees C for 30 min), trypsin sensitive, and neuraminidase resistant. LDCF-F could function to attact connective tissue fibroblasts to sites at which cell-mediated immune reactions are occurring in vivo.Entities:
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Year: 1976 PMID: 825607 PMCID: PMC2190454 DOI: 10.1084/jem.144.5.1188
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307