Literature DB >> 3098387

Chemotaxis of muscle-derived mesenchymal cells to bone-inductive proteins of rat.

R Landesman, A H Reddi.   

Abstract

In this investigation we examined the chemotaxis of muscle-derived mesenchymal cells from neonatal rats to partially purified extracts of demineralized bone matrix with osteoinductive properties. Using the modified Boyden chamber assay and muscle-derived mesenchymal cells obtained from neonatal Long-Evans rats, we tested the chemotactic properties of the 4 M guanidine-HCl extract from demineralized rat bone matrix and fractions thereof that were derived from sequential Sepharose CL-6B, TSK-3000 and HPLC-C18 chromatography. We have identified that those fractions exhibiting chemotactic properties were also osteoinductive. Therefore, demineralized bone matrix serves as its own soluble signal and insoluble substratum in the inductive process leading to endochondral bone formation in vivo.

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Year:  1986        PMID： 3098387     DOI： 10.1007/bf02555215

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  12 in total

1.  Biochemical sequences in the transformation of normal fibroblasts in adolescent rats.

Authors:  A H Reddi; C Huggins
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

2.  Bone: formation by autoinduction.

Authors:  M R Urist
Journal:  Science       Date:  1965-11-12       Impact factor: 47.728

3.  Alteration of the chemotactic response of NIH/3T3 cells to PDGF by growth factors, transformation, and tumor promoters.

Authors:  G R Grotendorst
Journal:  Cell       Date:  1984-02       Impact factor: 41.582

4.  Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

Authors:  G R Grotendorst; H E Seppä; H K Kleinman; G R Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

5.  Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation.

Authors:  T K Sampath; A H Reddi
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

6.  Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix.

Authors:  T K Sampath; A H Reddi
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

7.  Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.

Authors:  S H Zigmond; J G Hirsch
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

8.  Importance of geometry of the extracellular matrix in endochondral bone differentiation.

Authors:  T K Sampath; A H Reddi
Journal:  J Cell Biol       Date:  1984-06       Impact factor: 10.539

9.  The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor.

Authors:  A E Postlethwaite; R Snyderman; A H Kang
Journal:  J Exp Med       Date:  1976-11-02       Impact factor: 14.307

10.  Platelet-derived growth factor in chemotactic for fibroblasts.

Authors:  H Seppä; G Grotendorst; S Seppä; E Schiffmann; G R Martin
Journal:  J Cell Biol       Date:  1982-02       Impact factor: 10.539
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  3 in total

1.  In vivo analysis of the half-life of the osteoinductive potential of demineralized bone matrix using diffusion chambers.

Authors:  R Landesman; A H Reddi
Journal:  Calcif Tissue Int       Date:  1989-12       Impact factor: 4.333

Review 2.  Physiology of bone: mineral compartment proteins as candidates for environmental perturbation by lead.

Authors:  J J Sauk; M J Somerman
Journal:  Environ Health Perspect       Date:  1991-02       Impact factor: 9.031

3.  Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration.

Authors:  Rubén Aquino-Martínez; Alcira P Angelo; Francesc Ventura Pujol
Journal:  Stem Cell Res Ther       Date:  2017-11-16       Impact factor: 6.832
  3 in total

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