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Literature DB >> 2408968

Senile macular degeneration: the involvement of immunocompetent cells.

P L Penfold, M C Killingsworth, S H Sarks.

Abstract

Senile macular degeneration (SMD) is a leading cause of legal blindness in western countries. The role of immunocompetent cells in the pathogenesis of this disease has not been widely recognised. In this work specimens were studied by electron microscopy to provide ultrastructural details of the role of immunocompetent cells in early, intermediate and late stages of the disease. Additionally, we have analysed the frequency and distribution of inflammatory cellular infiltrates using wax histology. The results illustrate the involvement of macrophage-series cells, fibroblasts, lymphocytes and mast cells in neovascularisation, atrophy of the retinal pigment epithelium and the breakdown of Bruch's membrane. These observations, together with previous clinicopathological studies, have led us to suggest that SMD has a chronic inflammatory component.

Entities: Disease

Mesh：

Year: 1985 PMID： 2408968 DOI： 10.1007/bf02150948

Source DB: PubMed Journal: Graefes Arch Clin Exp Ophthalmol ISSN： 0721-832X Impact factor: 3.117

15 in total

1. Ageing and degeneration in the macular region: a clinico-pathological study.

Authors: S H Sarks
Journal: Br J Ophthalmol Date: 1976-05 Impact factor: 4.638

2. Activated macrophages induce vascular proliferation.

Authors: P J Polverini; P S Cotran; M A Gimbrone; E R Unanue
Journal: Nature Date: 1977-10-27 Impact factor: 49.962

Review 3. Granulomatous inflammations.

Authors: D L Boros
Journal: Prog Allergy Date: 1978

Senile macular degeneration: the involvement of immunocompetent cells.

1. Ageing and degeneration in the macular region: a clinico-pathological study.

2. Activated macrophages induce vascular proliferation.

Review 3. Granulomatous inflammations.

4. Council Lecture. Drusen and their relationship to senile macular degeneration.

5. Ageing changes in Bruch's membrane and their functional implications.

6. Softening of drusen and subretinal neovascularization.

7. Human monocyte stimulation of fibroblast growth by a soluble mediator(s).

8. Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor.

9. Immunologic and nonimmunologic activation of macrophages.

10. Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants.

1. Serum levels of antioxidants and age-related macular degeneration.

Review 2. Age-related macular degeneration: genetic and environmental factors of disease.

Review 3. Age-related macular degeneration and the immune response: implications for therapy.

4. Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis.

5. Macrophage polarization in the maculae of age-related macular degeneration: a pilot study.

6. Angiogenesis in early choroidal neovascularization secondary to age-related macular degeneration.

7. Fibronectin of the chorioretinal interface in the monkey: immunohistochemical and immunoelectron microscopic studies.

Review 8. Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

9. Asymmetry of disciform scarring in bilateral disease when one eye is treated with radiotherapy.

10. Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration.