Literature DB >> 8250606

Blocking cartilage destruction with metalloproteinase inhibitors: a valid therapeutic target?

T Cawston1.   

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Year:  1993        PMID: 8250606      PMCID: PMC1005185          DOI: 10.1136/ard.52.11.769

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN: 0003-4967            Impact factor:   19.103


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  14 in total

1.  Joint destruction in arthritis: metalloproteinases in the spotlight.

Authors:  C E Brinckerhoff
Journal:  Arthritis Rheum       Date:  1991-09

Review 2.  Rheumatoid arthritis--its present and future.

Authors:  M Ziff
Journal:  J Rheumatol       Date:  1990-02       Impact factor: 4.666

3.  Crystallization and preliminary X-ray analysis of porcine synovial collagenase.

Authors:  L F Lloyd; T Skarzyński; A J Wonacott; T E Cawston; I M Clark; C J Mannix; G P Harper
Journal:  J Mol Biol       Date:  1989-11-05       Impact factor: 5.469

4.  The role of proteases in matrix breakdown during cellular invasion.

Authors:  D B Rifkin; R Tsuboi; P Mignatti
Journal:  Am Rev Respir Dis       Date:  1989-10

Review 5.  Metalloproteinase inhibitors as therapeutics.

Authors:  J L Gordon; A H Drummond; W A Galloway
Journal:  Clin Exp Rheumatol       Date:  1993 Mar-Apr       Impact factor: 4.473

6.  Metalloproteinases and collagenase inhibitors in rheumatoid synovial fluid.

Authors:  T E Cawston; E Mercer; M de Silva; B L Hazleman
Journal:  Arthritis Rheum       Date:  1984-03

7.  The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor.

Authors:  T E Cawston; G Murphy; E Mercer; W A Galloway; B L Hazleman; J J Reynolds
Journal:  Biochem J       Date:  1983-05-01       Impact factor: 3.857

8.  Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin.

Authors:  G Murphy; T E Cawston; W A Galloway; M J Barnes; R A Bunning; E Mercer; J J Reynolds; R E Burgeson
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857

9.  Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn.

Authors:  J S Wentworth; C A Paterson; R D Gray
Journal:  Invest Ophthalmol Vis Sci       Date:  1992-06       Impact factor: 4.799

10.  A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro.

Authors:  H J Andrews; T A Plumpton; G P Harper; T E Cawston
Journal:  Agents Actions       Date:  1992-09
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  4 in total

1.  Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?

Authors:  D J Buttle; H Bramwell; A P Hollander
Journal:  Clin Mol Pathol       Date:  1995-08

2.  Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity.

Authors:  C J Brown; S Rahman; A C Morton; C L Beauchamp; H Bramwell; D J Buttle
Journal:  Clin Mol Pathol       Date:  1996-12

3.  Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

Authors:  A J Fosang; K Last; R A Maciewicz
Journal:  J Clin Invest       Date:  1996-11-15       Impact factor: 14.808

4.  Inhibition of relaxin-induced pubic symphyseal "relaxation" in guinea pigs by glycosaminoglycan polysulfates and pentosan polysulfate.

Authors:  B G Steinetz; G Lust
Journal:  Agents Actions       Date:  1994-08
  4 in total

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