Literature DB >> 2555522

Crystallization and preliminary X-ray analysis of porcine synovial collagenase.

L F Lloyd1, T Skarzyński, A J Wonacott, T E Cawston, I M Clark, C J Mannix, G P Harper.   

Abstract

Crystals of porcine synovial collagenase suitable for an X-ray structure analysis have been obtained. The crystals belong to space group I4, with unit cell dimensions a = b = 160.0 A, c = 53.1 A, with one molecule in the asymmetric unit. Diffraction extends beyond 3 A perpendicular to the c axis but along the 4-fold axis, the intensities are measurable only to 4 A.

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Year:  1989        PMID： 2555522     DOI： 10.1016/0022-2836(89)90304-5

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  3 in total

1.  Blocking cartilage destruction with metalloproteinase inhibitors: a valid therapeutic target?

Authors:  T Cawston
Journal:  Ann Rheum Dis       Date:  1993-11       Impact factor: 19.103

2.  Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1.

Authors:  Arjun S Adhikari; Jack Chai; Alexander R Dunn
Journal:  J Am Chem Soc       Date:  2011-01-19       Impact factor: 15.419

3.  A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro.

Authors:  H J Andrews; T A Plumpton; G P Harper; T E Cawston
Journal:  Agents Actions       Date:  1992-09
  3 in total

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