Literature DB >> 8247739

Misincorporation of ribonucleotides by DNA polymerase during in vitro DNA replication.

H Ide1, R Yagi, T Yamaoka, Y Kimura.   

Abstract

The fidelity of DNA replication with respect to misincorporation of ribonucleotides into DNA has been studied. Primed M13 DNA was replicated by E. coli DNA polymerase I in the presence of four dNTPs, a single rNTP and Mg2+ as a cofactor. All four rNTPs were incorporated into DNA in place of the corresponding dNTPs when rNTP/dNTP ratio was 1000:1. The frequency of rNTP misincorporation was C > G > A > U.

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Year:  1993        PMID： 8247739

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN： 0261-3166


  8 in total

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Review 3.  Ribonucleotides in bacterial DNA.

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  8 in total

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