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Literature DB >> 33461360

Ribonucleotide incorporation into DNA during DNA replication and its consequences.

Zhi-Xiong Zhou¹, Jessica S Williams¹, Scott A Lujan¹, Thomas A Kunkel¹.

Abstract

Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their vast presence and influence over genome biology is becoming increasingly appreciated. Here we review the recent progress made in understanding their genomic presence, incorporation characteristics and usefulness as biomarkers for polymerase enzymology. We also discuss ribonucleotide processing, the genetic consequences of unrepaired ribonucleotides in DNA and evidence supporting the significance of their transient presence in the nuclear genome.

Entities: Chemical Disease Gene Mutation Species

Keywords: DNA repair; DNA replication; Ribonucleotide incorporation; genome stability; genome-wide sequencing

Mesh：

Substances：

Year: 2021 PMID： 33461360 PMCID： PMC7936655 DOI： 10.1080/10409238.2020.1869175

Source DB: PubMed Journal: Crit Rev Biochem Mol Biol ISSN： 1040-9238 Impact factor: 8.250

123 in total

1. Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease.

Authors: J Qiu; Y Qian; P Frank; U Wintersberger; B Shen
Journal: Mol Cell Biol Date: 1999-12 Impact factor: 4.272

2. Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA.

Authors: Jessica S Williams; Scott A Lujan; Zhi-Xiong Zhou; Adam B Burkholder; Alan B Clark; David C Fargo; Thomas A Kunkel
Journal: DNA Repair (Amst) Date: 2019-07-03

3. Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ.

Authors: Anders R Clausen; Sufang Zhang; Peter M Burgers; Marietta Y Lee; Thomas A Kunkel
Journal: DNA Repair (Amst) Date: 2012-12-12

4. DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication.

Authors: Roberto A Donnianni; Zhi-Xiong Zhou; Scott A Lujan; Amr Al-Zain; Valerie Garcia; Eleanor Glancy; Adam B Burkholder; Thomas A Kunkel; Lorraine S Symington
Journal: Mol Cell Date: 2019-09-05 Impact factor: 17.970

5. Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.

Authors: Paulina H Wanrooij; Martin K M Engqvist; Josefin M E Forslund; Clara Navarrete; Anna Karin Nilsson; Juhan Sedman; Sjoerd Wanrooij; Anders R Clausen; Andrei Chabes
Journal: Proc Natl Acad Sci U S A Date: 2017-11-06 Impact factor: 11.205

6. Misincorporation of ribonucleotides by DNA polymerase during in vitro DNA replication.

Authors: H Ide; R Yagi; T Yamaoka; Y Kimura
Journal: Nucleic Acids Symp Ser Date: 1993

Review 7. Evolution of replicative DNA polymerases in archaea and their contributions to the eukaryotic replication machinery.

Authors: Kira S Makarova; Mart Krupovic; Eugene V Koonin
Journal: Front Microbiol Date: 2014-07-21 Impact factor: 5.640

8. Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.

Authors: Sathya Balachander; Alli L Gombolay; Taehwan Yang; Penghao Xu; Gary Newnam; Havva Keskin; Waleed M M El-Sayed; Anton V Bryksin; Sijia Tao; Nicole E Bowen; Raymond F Schinazi; Baek Kim; Kyung Duk Koh; Fredrik O Vannberg; Francesca Storici
Journal: Nat Commun Date: 2020-05-15 Impact factor: 14.919

9. Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.

Authors: Ryo Uehara; Susana M Cerritelli; Naushaba Hasin; Kiran Sakhuja; Mariya London; Jaime Iranzo; Hyongi Chon; Alexander Grinberg; Robert J Crouch
Journal: Cell Rep Date: 2018-10-30 Impact factor: 9.423