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Literature DB >> 6195156

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

Abstract

The enzyme which confers resistance to erythromycin in the producing organism Streptomyces erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S rRNA. This corresponds to residue Ade 2058 in Escherichia coli 23 S RNA. The methylase responsible for resistance to macrolides, lincomycin, and streptogramin B-related antibiotics in Staphylococcus aureus also acts at this site.

Entities: Chemical Species

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Year: 1983 PMID： 6195156

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

88 in total

1. Negative in vitro selection identifies the rRNA recognition motif for ErmE methyltransferase.

Authors: A K Nielsen; S Douthwaite; B Vester
Journal: RNA Date: 1999-08 Impact factor: 4.942

Review 2. Macrolide resistance conferred by base substitutions in 23S rRNA.

Authors: B Vester; S Douthwaite
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

3. Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions.

Authors: Gordana Maravić; Janusz M Bujnicki; Marcin Feder; Sándor Pongor; Mirna Flögel
Journal: Nucleic Acids Res Date: 2003-08-15 Impact factor: 16.971

4. Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.

Authors: C Vilches; C Hernandez; C Mendez; J A Salas
Journal: J Bacteriol Date: 1992-01 Impact factor: 3.490

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

1. Negative in vitro selection identifies the rRNA recognition motif for ErmE methyltransferase.

Review 2. Macrolide resistance conferred by base substitutions in 23S rRNA.

3. Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions.

4. Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.

Review 5. Avoidance of suicide in antibiotic-producing microbes.

6. Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase.

7. 23S rRNA domain V, a fragment that can be specifically methylated in vitro by the ErmSF (TlrA) methyltransferase.

8. Substrate requirements for ErmC' methyltransferase activity.

9. Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.

10. Novel mechanisms of resistance to lincosamides in Staphylococcus and Arthrobacter spp.