Literature DB >> 8199241

Methionine as translation start signal: a review of the enzymes of the pathway in Escherichia coli.

T Meinnel1, Y Mechulam, S Blanquet.   

Abstract

Methionine is the universal translation start but the first methionine is removed from most mature proteins. This review focuses on our present knowledge of the five enzymes sustaining the methionine pathway in translation initiation in Escherichia coli: methionyl-tRNA synthetase, methionyl-tRNA(fMet) formyltransferase, peptidyl-tRNA hydrolase, peptide deformylase and methionine aminopeptidase. The possible significance of retaining methionine as initiation signal is discussed.

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Year:  1993        PMID： 8199241     DOI： 10.1016/0300-9084(93)90005-d

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  58 in total

1.  Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms.

Authors:  C Giglione; A Serero; M Pierre; B Boisson; T Meinnel
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

2.  A ribozyme that ligates RNA to protein.

Authors:  Scott Baskerville; David P Bartel
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-20       Impact factor: 11.205

3.  Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.

Authors:  Qing Xiao; Feiran Zhang; Benjamin A Nacev; Jun O Liu; Dehua Pei
Journal:  Biochemistry       Date:  2010-07-06       Impact factor: 3.162

4.  Omics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion.

Authors:  Veronique Jonckheere; Daria Fijałkowska; Petra Van Damme
Journal:  Mol Cell Proteomics       Date:  2018-01-09       Impact factor: 5.911

5.  Development and validation of a whole-cell inhibition assay for bacterial methionine aminopeptidase by surface-enhanced laser desorption ionization-time of flight mass spectrometry.

Authors:  Kenneth D Greis; Songtao Zhou; Richard Siehnel; Chuck Klanke; Alan Curnow; Jeremy Howard; Gerlinde Layh-Schmitt
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

6.  p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils.

Authors:  Kendra D Martyn; Moon-Ju Kim; Mark T Quinn; Mary C Dinauer; Ulla G Knaus
Journal:  Blood       Date:  2005-08-11       Impact factor: 22.113

7.  Heterologous expression and purification of Vibrio proteolyticus (Aeromonas proteolytica) aminopeptidase: a rapid protocol.

Authors:  Mariam Hartley; Wei Yong; Brian Bennett
Journal:  Protein Expr Purif       Date:  2009-02-20       Impact factor: 1.650

8.  Characterization of the active site and insight into the binding mode of the anti-angiogenesis agent fumagillin to the manganese(II)-loaded methionyl aminopeptidase from Escherichia coli.

Authors:  Ventris M D'souza; Robert S Brown; Brian Bennett; Richard C Holz
Journal:  J Biol Inorg Chem       Date:  2004-12-01       Impact factor: 3.358

9.  Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.

Authors:  T Meinnel; S Blanquet
Journal:  J Bacteriol       Date:  1994-12       Impact factor: 3.490

10.  Mutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli.

Authors:  Sanghamitra Mitra; Brian Bennett; Richard C Holz
Journal:  Biochim Biophys Acta       Date:  2008-10-07
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