Literature DB >> 7961514

Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.

T Meinnel1, S Blanquet.   

Abstract

An Escherichia coli strain with thermosensitive expression of the gene encoding peptide deformylase (fms) has been constructed. At nonpermissive temperatures, this strain fails to grow. The essential character of the fms gene was further used to clone by heterologous complementation the locus corresponding to Thermus thermophilus peptide deformylase. The cloned fragment also carries the methionyl-tRNA(fMet) formyltransferase gene (fmt). It is located immediately downstream from the fms gene, as in E. coli. Further sequence analysis of the region surrounding the E. coli fms-fmt locus indicates that the genes bordering the fms-fmt region are not conserved in T. thermophilus.

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Year:  1994        PMID： 7961514      PMCID： PMC197131          DOI： 10.1128/jb.176.23.7387-7390.1994

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

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5.  pepM is an essential gene in Salmonella typhimurium.

Authors:  C G Miller; A M Kukral; J L Miller; N R Movva
Journal:  J Bacteriol       Date:  1989-09       Impact factor: 3.490

6.  Improved tools for biological sequence comparison.

Authors:  W R Pearson; D J Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

7.  Deformylation and protein biosynthesis.

Authors:  D M Livingston; P Leder
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Authors:  C V Jongeneel; J Bouvier; A Bairoch
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Authors:  L N Csonka; A J Clark
Journal:  J Bacteriol       Date:  1980-07       Impact factor: 3.490
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  30 in total

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Authors:  C Giglione; A Serero; M Pierre; B Boisson; T Meinnel
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

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5.  Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.

Authors:  Yann Duroc; Carmela Giglione; Thierry Meinnel
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7.  Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.

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8.  Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus.

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9.  Expression of Escherichia coli methionyl-tRNA formyltransferase in Saccharomyces cerevisiae leads to formylation of the cytoplasmic initiator tRNA and possibly to initiation of protein synthesis with formylmethionine.

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10.  Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.

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