UNLABELLED: A Phase II trial of 75 mCi/m2 131I-anti-TAG-72 high-affinity antibody CC49 was studied in 15 patients with hormone-resistant metastatic prostate cancer. METHODS: Patients had adequate renal, liver and hematopoietic function. No previous cytotoxic chemotherapy was allowed and previous radiation was limited to 20% of the active bone marrow. RESULTS: No acute adverse reactions occurred, but all patients had evidence of an immune response to CC49 by 4 wk. Six of 10 symptomatic patients had bone pain relief, but no patients met the radiographic or PSA criteria for objective response. Positive imaging of bone and/or soft-tissue lesions was noted for 13 of the 15 patients. CONCLUSIONS: CC49 had a high frequency of tumor localization with evidence of anti-tumor effects (pain relief).
UNLABELLED: A Phase II trial of 75 mCi/m2 131I-anti-TAG-72 high-affinity antibody CC49 was studied in 15 patients with hormone-resistant metastatic prostate cancer. METHODS:Patients had adequate renal, liver and hematopoietic function. No previous cytotoxic chemotherapy was allowed and previous radiation was limited to 20% of the active bone marrow. RESULTS: No acute adverse reactions occurred, but all patients had evidence of an immune response to CC49 by 4 wk. Six of 10 symptomatic patients had bone pain relief, but no patients met the radiographic or PSA criteria for objective response. Positive imaging of bone and/or soft-tissue lesions was noted for 13 of the 15 patients. CONCLUSIONS: CC49 had a high frequency of tumor localization with evidence of anti-tumor effects (pain relief).
Authors: Benjamin Cahan; Lucille Leong; Lawrence Wagman; David Yamauchi; Stephen Shibata; Sharon Wilzcynski; Lawrence E Williams; Paul Yazaki; David Colcher; Paul Frankel; Anna Wu; Andrew Raubitschek; John Shively; Jeffrey Y C Wong Journal: Cancer Biother Radiopharm Date: 2017-09 Impact factor: 3.099
Authors: David Akhavan; Paul Yazaki; Dave Yamauchi; Jennifer Simpson; Paul H Frankel; James Bading; David Colcher; Kofi Poku; Yi-Jen Chen; Dean Lim; Mihaela Cristea; Anna Wu; John Shively; Jeffrey Y C Wong Journal: Cancer Biother Radiopharm Date: 2020-01-07 Impact factor: 3.099
Authors: Kirsten Bouchelouche; Scott T Tagawa; Stanley J Goldsmith; Baris Turkbey; Jacek Capala; Peter Choyke Journal: Semin Nucl Med Date: 2011-01 Impact factor: 4.446