Literature DB >> 8186238

The solvent dependence of enzyme specificity.

C R Wescott1, A M Klibanov.   

Abstract

The discovery that enzymes possess catalytic activity in organic solvents has made it possible to address the question of the influence of the reaction medium on enzymatic specificity. Recently, the substrate specificity, enantioselectivity, prochiral selectivity, regioselectivity, and chemoselectivity of enzymes have been found to dramatically depend on the nature of the solvent. This review discusses the scope, possible mechanisms, and implications of this phenomenon, as well as directions of future research in the area.

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Year:  1994        PMID： 8186238     DOI： 10.1016/0167-4838(94)90065-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  15 in total

1.  Analysis of the conformational stability and activity of Candida antarctica lipase B in organic solvents: insight from molecular dynamics and quantum mechanics/simulations.

Authors:  Cong Li; Tianwei Tan; Haiyang Zhang; Wei Feng
Journal:  J Biol Chem       Date:  2010-07-03       Impact factor: 5.157

2.  Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.

Authors:  J L Schmitke; L J Stern; A M Klibanov
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

3.  Interfacial activation-based molecular bioimprinting of lipolytic enzymes.

Authors:  I Mingarro; C Abad; L Braco
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

4.  Matrix-assisted laser desorption ionization hydrogen/deuterium exchange studies to probe peptide conformational changes.

Authors:  I D Figueroa; D H Russell
Journal:  J Am Soc Mass Spectrom       Date:  1999-08       Impact factor: 3.109

5.  Correct protein folding in glycerol.

Authors:  R V Rariy; A M Klibanov
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

6.  Crystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexane.

Authors:  X G Gao; E Maldonado; R Pérez-Montfort; G Garza-Ramos; M T de Gómez-Puyou; A Gómez-Puyou; A Rodríguez-Romero
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

7.  Synthesis of fatty acid esters and diacylglycerols at elevated temperatures by alkalithermophilic lipases from Thermosyntropha lipolytica.

Authors:  Moh'd A Salameh; Juergen Wiegel
Journal:  J Ind Microbiol Biotechnol       Date:  2009-07-11       Impact factor: 3.346

8.  Hydrogen/deuterium exchange study of subtilisin Carlsberg during prolonged exposure to organic solvents.

Authors:  Ezio Fasoli; Amaris Ferrer; Gabriel L Barletta
Journal:  Biotechnol Bioeng       Date:  2009-03-01       Impact factor: 4.530

9.  Ester Cross-Link Profiling of the Cutin Polymer of Wild-Type and Cutin Synthase Tomato Mutants Highlights Different Mechanisms of Polymerization.

Authors:  Glenn Philippe; Cédric Gaillard; Johann Petit; Nathalie Geneix; Michèle Dalgalarrondo; Cécile Bres; Jean-Philippe Mauxion; Rochus Franke; Christophe Rothan; Lukas Schreiber; Didier Marion; Bénédicte Bakan
Journal:  Plant Physiol       Date:  2015-12-16       Impact factor: 8.340

10.  Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine-containing substrates.

Authors:  Verena Resch; Horst Lechner; Joerg H Schrittwieser; Silvia Wallner; Karl Gruber; Peter Macheroux; Wolfgang Kroutil
Journal:  Chemistry       Date:  2012-09-07       Impact factor: 5.236
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