Literature DB >> 8178937

Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.

T R Ulich1, E S Yi, R Cardiff, S Yin, N Bikhazi, R Biltz, C F Morris, G F Pierce.   

Abstract

Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor (FGF) family. KGF is secreted by stromal cells and affects epithelial but not mesenchymal cell proliferation. KGF injected intravenously was found to cause dramatic proliferation of mammary epithelium in the mammary glands of rats. KGF causes ductal neogenesis and intraductal epithelial hyperplasia but not lobular differentiation in nulliparous female rats. KGF causes ductal and lobular epithelial hyperplasia in male rats. KGF causes proliferation of ductal and acinar cells in the mammary glands of pregnant rats. On the other hand, the ductal epithelium of lactating postpartum rats is resistant to the proliferative action of KGF. The mammary glands of lactating rats did not express less KGF receptor mRNA than the glands of pregnant rats, suggesting that the resistance of the ductal epithelium to KGF during lactation is not related to KGF receptor mRNA down-regulation. The mammary glands of both pregnant and postpartum lactating rats express KGF mRNA with more KGF present in the glands of lactating rats. In conclusion, the KGF and KGF receptor genes are expressed in rat mammary glands and recombinant KGF is a potent growth factor for mammary epithelium.

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Year:  1994        PMID： 8178937      PMCID： PMC1887355     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  11 in total

1.  Purification and characterization of a newly identified growth factor specific for epithelial cells.

Authors:  J S Rubin; H Osada; P W Finch; W G Taylor; S Rudikoff; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

2.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

3.  Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.

Authors:  P W Finch; J S Rubin; T Miki; D Ron; S A Aaronson
Journal:  Science       Date:  1989-08-18       Impact factor: 47.728

4.  Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction.

Authors:  R D Koos; P K Banks; S E Inkster; W Yue; A M Brodie
Journal:  J Steroid Biochem Mol Biol       Date:  1993-04       Impact factor: 4.292

5.  Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.

Authors:  T Miki; T P Fleming; D P Bottaro; J S Rubin; D Ron; S A Aaronson
Journal:  Science       Date:  1991-01-04       Impact factor: 47.728

6.  A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity.

Authors:  K R Dell; L T Williams
Journal:  J Biol Chem       Date:  1992-10-15       Impact factor: 5.157

7.  Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

Authors:  A Tanaka; K Miyamoto; N Minamino; M Takeda; B Sato; H Matsuo; K Matsumoto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

8.  A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site.

Authors:  D P Bottaro; E Fortney; J S Rubin; S A Aaronson
Journal:  J Biol Chem       Date:  1993-05-05       Impact factor: 5.157

9.  Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

Authors:  T Miki; D P Bottaro; T P Fleming; C L Smith; W H Burgess; A M Chan; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

10.  Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

Authors:  G Yan; Y Fukabori; S Nikolaropoulos; F Wang; W L McKeehan
Journal:  Mol Endocrinol       Date:  1992-12
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  38 in total

1.  Regulation of keratinocyte growth factor (KGF) and KGF receptor mRNAs by nutrient intake and KGF administration in rat intestine.

Authors:  C F Estívariz; L H Gu; S Scully; A Eli; C R Jonas; C L Farrell; T R Ziegler
Journal:  Dig Dis Sci       Date:  2000-04       Impact factor: 3.199

Review 2.  A role for epithelial gamma delta T cells in tissue repair.

Authors:  D A Witherden; S E Rieder; R Boismenu; W L Havran
Journal:  Springer Semin Immunopathol       Date:  2000

Review 3.  Intraepithelial gamma delta T lymphocytes: sentinel cells at mucosal barriers.

Authors:  D A Ferrick; D P King; K A Jackson; R K Braun; S Tam; D M Hyde; B L Beaman
Journal:  Springer Semin Immunopathol       Date:  2000

Review 4.  Progesterone signaling and mammary gland morphogenesis.

Authors:  G Shyamala
Journal:  J Mammary Gland Biol Neoplasia       Date:  1999-01       Impact factor: 2.673

Review 5.  Role of mesenchymal-epithelial interactions in mammary gland development.

Authors:  G R Cunha; Y K Hom
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-01       Impact factor: 2.673

Review 6.  A role for fibroblast growth factor signaling in the lobuloalveolar development of the mammary gland.

Authors:  D Jackson; J Bresnick; C Dickson
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-10       Impact factor: 2.673

Review 7.  A crucial role for fibroblast growth factor signaling in embryonic mammary gland development.

Authors:  Christian Dillon; Bradley Spencer-Dene; Clive Dickson
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-04       Impact factor: 2.673

Review 8.  Epithelia: lymphocyte interactions in the gut.

Authors:  Stephanie Dahan; Franziska Roth-Walter; Paul Arnaboldi; Shradha Agarwal; Lloyd Mayer
Journal:  Immunol Rev       Date:  2007-02       Impact factor: 12.988

9.  Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

Authors:  R M Housley; C F Morris; W Boyle; B Ring; R Biltz; J E Tarpley; S L Aukerman; P L Devine; R H Whitehead; G F Pierce
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

10.  Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice.

Authors:  Dachun Wang; John E Morales; Daniel G Calame; Joseph L Alcorn; Rick A Wetsel
Journal:  Mol Ther       Date:  2010-01-19       Impact factor: 11.454
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