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Literature DB >> 81677

Influence of hydrocortisone on the modulation of the inflammatory response.

Abstract

In vitro hydrocortisone, in pharmacologically attainable concentrations, binds nonspecifically to rat peritoneal mast cells and amplifies the stimulating effects of PGE1 on membrane-bound adenylate cyclase. As a consequence, the intracellular concentration of cyclic AMP in the target cells increases and histamine release is markedly reduced. Deoxycorticosterone, at the same concentrations, has no effect. These findings may in part explain the mechanism of action of anti-inflammatory steroids, possibly related to the modulating effects of E-type prostaglandins.

Entities: Chemical Species

Mesh：

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Year: 1978 PMID： 81677 PMCID： PMC2041368

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

25 in total

1. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.

Authors: G P Lewis; P J Piper
Journal: Nature Date: 1975-03-27 Impact factor: 49.962

1. Hydrocortisone increases the responsiveness of mast cells to beta-adrenergic agonists by an action distal to the beta-adrenoreceptors.

Authors: G Tolone; L Bonasera; R Sajeva
Journal: Br J Exp Pathol Date: 1979-06

Influence of hydrocortisone on the modulation of the inflammatory response.

1. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.

2. Glucocorticoid receptors in purified subpopulations of human peripheral blood lymphocytes.

3. Specific glucocorticoid inhibition of growth promoting effects of prostaglandin F2alpha on 3T3 cells.

4. Concanavalin A-induced histamine release from normal rat mast cells.

5. Effects of colchicine on cyclic AMP levels in human leukocytes.

Review 6. Glucocorticosteroid therapy: mechanisms of action and clinical considerations.

7. Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic, and physical stimuli.

8. Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

9. Fibroblast heterogeneity and prostaglandin regulation of subpopulations.

10. Biosynthesis and release of prostaglandins by mast cells.

1. Hydrocortisone increases the responsiveness of mast cells to beta-adrenergic agonists by an action distal to the beta-adrenoreceptors.

2. Influence of glucocorticoids on histamine release and 45calcium uptake by isolated rat mast cells.

3. Effect of corticosteroids on indomethacin-induced intestinal ulceration in the rat.

4. Influence of prednisolone on ethanol-induced gastric injury in the rat.