Literature DB >> 1064044

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

S L Hong, L Levine.   

Abstract

Serum stimulates the production of prostaglandins by transformed mouse fibroblasts. Hydrocortisone (cortisol) inhibits this stimulation. The half-maximal inhibition occurs at 6x10-9 M. Studies with cells labeled with [3H]arachidonic acid in their lipids show that the stimulation by serum results in the release of arachidonic acid from the cellular lipids, mostly phospholipids. Hydrocrotisone inhibits this release but does not inhibit the production of prostaglandins from exogenously supplied arachidonic acid. This inhibition of arachidonic acid release from phospholipids may be the mechanism for the anti-inflammatory action of corticosteroids.

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Year:  1976        PMID： 1064044      PMCID： PMC430374          DOI： 10.1073/pnas.73.5.1730

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Studies on lysosomes. II. The effect of cortisone on the release of acid hydrolases from a large granule fraction of rabbit liver induced by an excess of vitamin A.

Authors:  G WEISSMANN; L THOMAS
Journal:  J Clin Invest       Date:  1963-05       Impact factor: 14.808

2.  Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.

Authors:  G P Lewis; P J Piper
Journal:  Nature       Date:  1975-03-27       Impact factor: 49.962

Review 3.  Biological significance of the prostaglandins.

Authors:  P W Ramwell; J E Shaw
Journal:  Recent Prog Horm Res       Date:  1970

4.  Superinduction of endogenous type C virus by 5-bromodeoxyuridine from transformed mouse clones.

Authors:  M M Lieber; D M Livingston; G J Todaro
Journal:  Science       Date:  1973-08-03       Impact factor: 47.728

5.  Effects of anti-inflammatory drugs on prostaglandin biosynthesis.

Authors:  R Flower; R Gryglewski; K Herbaczyńska-Cedro; J R Vane
Journal:  Nat New Biol       Date:  1972-07-26

6.  Action of anti-inflammatory steroids on the lytic action of phospholipase C and 2,4,6-trinitrobenzene sulphonic acid on lysosomes.

Authors:  D A Lewis; A M Symons; R J Ancill
Journal:  Biochem Pharmacol       Date:  1974-01-15       Impact factor: 5.858

7.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

8.  Lipids of Salmonella typhimurium and Escherichia coli: structure and metabolism.

Authors:  G F Ames
Journal:  J Bacteriol       Date:  1968-03       Impact factor: 3.490

9.  Effects of steroid hormones on human polymorphonuclear leukocyte lysosomes.

Authors:  R H Persellin; L C Ku
Journal:  J Clin Invest       Date:  1974-10       Impact factor: 14.808

10.  Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids.

Authors:  M W Greaves; W McDonald-Gibson
Journal:  Br J Pharmacol       Date:  1972-09       Impact factor: 8.739
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  108 in total

1.  Changes in corticosterone levels under different degrees of acute inflammation in mice.

Authors:  S L Chio; Y M Sin
Journal:  Agents Actions       Date:  1992-05

2.  The remarkable contributions of S. Burt Wolbach on rickettsial vasculitis updated.

Authors:  T E Woodward; D H Walker; J S Dumler
Journal:  Trans Am Clin Climatol Assoc       Date:  1992

3.  Glucocorticoids increase the responsiveness of cells in culture to prostaglandin E1.

Authors:  S J Foster; J P Perkins
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

Review 4.  Prostaglandin-mediated hypercalcemia: a paraneoplastic syndrome.

Authors:  H W Seyberth
Journal:  Klin Wochenschr       Date:  1978-04-15

5.  Despite a massive increase in cortisol secretion in women during parturition, there is an equally massive increase in prostaglandin synthesis. A paradox?

Authors:  M L Casey; P C MacDonald; M D Mitchell
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

6.  Effect of dexamethasone on in vivo prostanoid production in the rabbit.

Authors:  A Náray-Fejes-Tóth; G Fejes-Tóth; C Fischer; J C Frölich
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

7.  Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo-oxygenase/PGE isomerase.

Authors:  M Goppelt-Struebe; D Wolter; K Resch
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

8.  The effect of systemic prednisolone on arachidonic acid, and prostaglandin E2 and F2 alpha levels in human cutaneous inflammation.

Authors:  A Kobza Black; M W Greaves; C N Hensby
Journal:  Br J Clin Pharmacol       Date:  1982-09       Impact factor: 4.335

9.  Dexamethasone increases the synthesis of sphingomyelin in 3T3-L1 cell membranes.

Authors:  D H Nelson; D K Murray
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

10.  Characterization and partial purification of 'renocortins': two polypeptides formed in renal cells causing the anti-phospholipase-like action of glucocorticoids.

Authors:  J F Cloix; O Colard; B Rothhut; F Russo-Marie
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739
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