Literature DB >> 8152

Role of lysyl-tRNA in the regulation of lysine biosynthesis in Escherichia coli K12.

E Boy, F Reinisch, C Richaud, J C Patte.   

Abstract

A mutant of lysyl-tRNA synthetase has been isolated in Escherichia coli K12. With this strain the Kmapp for lysine is 25 fold higher than with the parental strain. The percentage of charged tRNAlys in vivo is only 7 per cent (as against 65 per cent with HFR H). Under these conditions no derepression of synthesis is observed for three lysine biosynthetic enzymes (AK III, ASA-dehydrogenase, DAP-decarboxylase) ; a partial derepression is obtained in the case of the dhdp-reductase. Thus lysyl-tRNA does not act as the only corepressor molecule in the lysine regulon.

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Year:  1976        PMID： 8152     DOI： 10.1016/s0300-9084(76)80372-0

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  6 in total

1.  Effect of mutations affecting lysyl-tRNAlys on the regulation of lysine biosynthesis in Escherichia coli.

Authors:  E Boy; F Borne; J C Patte
Journal:  Mol Gen Genet       Date:  1978-02-07

2.  Partial characterization of a lysU mutant of Escherichia coli K-12.

Authors:  M Hassani; M V Saluta; G N Bennett; I N Hirshfield
Journal:  J Bacteriol       Date:  1991-03       Impact factor: 3.490

3.  Heterologous expression and regulation of the lysA genes of Pseudomonas aeruginosa and Escherichia coli.

Authors:  C Martin; B Cami; F Borne; D J Jeenes; D Haas; J C Patte
Journal:  Mol Gen Genet       Date:  1986-06

4.  Threonyl-transfer ribonucleic acid synthetase and the regulation of the threonine operon in Escherichia coli.

Authors:  E J Johnson; G N Cohen; I Saint-Girons
Journal:  J Bacteriol       Date:  1977-01       Impact factor: 3.490

5.  The relA locus and the regulation of lysine biosynthesis in Escherichia coli.

Authors:  J C Patte; P Morand; E Boy; C Richaud; F Borne
Journal:  Mol Gen Genet       Date:  1980

6.  Construction of hybrid plasmids containing the lysA gene of Escherichia coli: studies of expression in Escherichia coli and Saccharomyces cerevisiae.

Authors:  J Chenais; C Richaud; J Ronceray; H Cherest; Y Surdin-Kerjan; J C Patte
Journal:  Mol Gen Genet       Date:  1981
  6 in total

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