Literature DB >> 6110161

The relA locus and the regulation of lysine biosynthesis in Escherichia coli.

J C Patte, P Morand, E Boy, C Richaud, F Borne.   

Abstract

The allelic state of relA influences the phenotype of Escherichia coli strains carrying the lysA22 mutation:lysA22 relA strains are Lys- where lysA22 relA+ strains grow (slowly) in the absence of lysine. This physiological effect has been related to an effect of the expression of the relA locus on the regulation of lysine biosynthesis. The fully derepressed levels of some lysine enzymes (aspartokinase III, aspartic semialdehyde dehydrogenase, didhydrodipicolinate reductase) are observed under lysine limitation only in rel+ strains. And the induction of DAP-decarboxylase by DAP is much higher in rel+ than in rel- strains when an amino acid limitation of growth is also realised. These results are in agreement with the hypothesis of Stephens et al. (1975) on a possible role of the stringent regulation as a general signal for amino acid deficiency.

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Year:  1980        PMID： 6110161     DOI： 10.1007/bf00425459

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  37 in total

1.  IMPROVED METHOD FOR THE ISOLATION OF THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI.

Authors:  K A STACEY; E SIMSON
Journal:  J Bacteriol       Date:  1965-08       Impact factor: 3.490

2.  Cyclic AMP can replace the relA-dependent requirement for derepression of acetohydroxy acid synthase in E. coli K-12.

Authors:  M Freundlich
Journal:  Cell       Date:  1977-12       Impact factor: 41.582

3.  A rapid test for the rel A mutation in E. coli.

Authors:  M Uzan; A Danchin
Journal:  Biochem Biophys Res Commun       Date:  1976-04-05       Impact factor: 3.575

4.  Subunits of RNA polymerase in function and structure. IX. Regulation of RNA polymerase activity by stringent starvation protein (SSP).

Authors:  A Ishihama; T Saitoh
Journal:  J Mol Biol       Date:  1979-04-25       Impact factor: 5.469

5.  rel-dependent methionine requirement in revertants of a methionyl-transfer RNA synthetase mutant of Escherichia coli.

Authors:  C R Somerville; A Ahmed
Journal:  J Mol Biol       Date:  1977-03-25       Impact factor: 5.469

6.  Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants.

Authors:  C B Bruni; V Colantuoni; L Sbordone; R Cortese; F Blasi
Journal:  J Bacteriol       Date:  1977-04       Impact factor: 3.490

7.  DNA repair and genetic recombination: studies on mutants of Escherichia coli defective in these processes.

Authors:  P Howard-Flanders; R P Boyce
Journal:  Radiat Res       Date:  1966       Impact factor: 2.841

8.  Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency.

Authors:  J C Stephens; S W Artz; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

9.  Dual-control of the tryptophan operon is mediated by both tryptophanyl-tRNA synthetase and the repressor.

Authors:  D E Morse; A N Morse
Journal:  J Mol Biol       Date:  1976-05-15       Impact factor: 5.469

10.  Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli.

Authors:  E E Ishiguro; W D Ramey
Journal:  J Bacteriol       Date:  1978-09       Impact factor: 3.490
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  8 in total

1.  Multiple regulatory signals in the control region of the Escherichia coli carAB operon.

Authors:  J Bouvier; J C Patte; P Stragier
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

2.  Regulatory pattern of the Escherichia coli lysA gene: expression of chromosomal lysA-lacZ fusions.

Authors:  P Stragier; F Borne; F Richaud; C Richaud; J C Patte
Journal:  J Bacteriol       Date:  1983-12       Impact factor: 3.490

3.  Heterologous expression and regulation of the lysA genes of Pseudomonas aeruginosa and Escherichia coli.

Authors:  C Martin; B Cami; F Borne; D J Jeenes; D Haas; J C Patte
Journal:  Mol Gen Genet       Date:  1986-06

4.  Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator.

Authors:  Jean Bouvier; Patrick Stragier; Violette Morales; Elisabeth Rémy; Claude Gutierrez
Journal:  J Bacteriol       Date:  2008-05-23       Impact factor: 3.490

5.  Construction of hybrid plasmids containing the lysA gene of Escherichia coli: studies of expression in Escherichia coli and Saccharomyces cerevisiae.

Authors:  J Chenais; C Richaud; J Ronceray; H Cherest; Y Surdin-Kerjan; J C Patte
Journal:  Mol Gen Genet       Date:  1981

6.  Nucleotide sequence of the lysA gene of Corynebacterium glutamicum and possible mechanisms for modulation of its expression.

Authors:  P Yeh; A M Sicard; A J Sinskey
Journal:  Mol Gen Genet       Date:  1988-04

7.  Nucleotide sequence of the promoter region of the E. coli lysC gene.

Authors:  M Cassan; J Ronceray; J C Patte
Journal:  Nucleic Acids Res       Date:  1983-09-24       Impact factor: 16.971

8.  Nucleotide sequence of the asd gene of Escherichia coli: absence of a typical attenuation signal.

Authors:  C Haziza; P Stragier; J C Patte
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
  8 in total

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