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Literature DB >> 345082

Effect of mutations affecting lysyl-tRNAlys on the regulation of lysine biosynthesis in Escherichia coli.

Abstract

When studying mutants affecting lysyl-tRNA synthetase or tRNAlys (hisT, hisW), a lack of correlation is clearly observed between the amount of lysyl-tRNA and the level of derepression of several lysine biosynthetic enzymes. This exlcudes the possible role of lysyl-tRNA as the specific corepressor of the lysine regulon. However, the level of derepression of DAP-decarboxylase, the last enzyme of the lysine pathway, is very low in the hisT mutant; this indicates that tRNAlys is a secondary effector involved in the regulation of the synthesis of this enzyme.

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Year: 1978 PMID： 345082 DOI： 10.1007/bf00401745

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

18 in total

1. Reduced maximal levels of derepression of the isoleucine-valine and leucine enzymes in hisT mutants of Salmonella typhimurium.

Authors: R S Bresalier; A A Rizzino; M Freundlich
Journal: Nature Date: 1975-01-24 Impact factor: 49.962

2. Repression of the tyrosine, lysine, and methionine biosynthetic pathways in a hisT mutant of Salmonella typhimurium.

Authors: B A Brown; S R Lax; L Liang; B J Dabney; L L Spremulli; J M Ravel
Journal: J Bacteriol Date: 1977-02 Impact factor: 3.490

3. [Repression of meso-alpha, epsilon-diaminopimelic acid decarboxylase by L-lysine in Escherichia coli].

Authors: J C PATTE; T LOVINY; G N COHEN
Journal: Biochim Biophys Acta Date: 1962-04-09

4. An in vivo effect of the metabolites L-alanine and glycyl-L-leucine on the properties of lysyl-tRNA synthetase from Escherichia coli K-12. I. Influence on subunit composition and molecular weight distribution.

Authors: I N Hirshfield; F M Yeh; P C Zamecnik
Journal: Biochim Biophys Acta Date: 1976-07-02

3. Isolation of the gene (miaE) encoding the hydroxylase involved in the synthesis of 2-methylthio-cis-ribozeatin in tRNA of Salmonella typhimurium and characterization of mutants.

Authors: B C Persson; G R Björk
Journal: J Bacteriol Date: 1993-12 Impact factor: 3.490

3 in total

Effect of mutations affecting lysyl-tRNAlys on the regulation of lysine biosynthesis in Escherichia coli.

1. Reduced maximal levels of derepression of the isoleucine-valine and leucine enzymes in hisT mutants of Salmonella typhimurium.

2. Repression of the tyrosine, lysine, and methionine biosynthetic pathways in a hisT mutant of Salmonella typhimurium.

3. [Repression of meso-alpha, epsilon-diaminopimelic acid decarboxylase by L-lysine in Escherichia coli].

4. An in vivo effect of the metabolites L-alanine and glycyl-L-leucine on the properties of lysyl-tRNA synthetase from Escherichia coli K-12. I. Influence on subunit composition and molecular weight distribution.

5. Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants.

6. [Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications].

7. Characterization of a cold-sensitive hisW mutant of Salmonella typhimurium.

8. Dual-control of the tryptophan operon is mediated by both tryptophanyl-tRNA synthetase and the repressor.

9. Metabolites influence control of lysine transfer ribonucleic acid synthetase formation in Escherichia coli K-12.

10. The regulation of diaminopimelate decarboxylase activity in Escherichia coli strain w.

1. Escherichia coli K-12 lysyl-tRNA synthetase mutant with a novel reversion pattern.

2. The relA locus and the regulation of lysine biosynthesis in Escherichia coli.

3. Isolation of the gene (miaE) encoding the hydroxylase involved in the synthesis of 2-methylthio-cis-ribozeatin in tRNA of Salmonella typhimurium and characterization of mutants.