Literature DB >> 8151648

Analysis of human growth hormone gene 5' sequences in isolated growth hormone deficiency patients.

Y Wang1, L L Yu, Q Sheng, C Meng, J Sun, S S Chen.   

Abstract

Human growth hormone (hGH) gene deletion (6.7 to 7.6 kb) is one of the causes of isolated growth hormone deficiency (IGHD), named IGHD IA. IGHD IA, however, only accounts for about 10% of the total IGHD patients. Most IGHD is caused by unknown mechanisms. Here, hGH gene 5' sequences in three IGHD patients without hGH gene deletion were analysed to see if there was any mutation hindering the expression of the hGH gene.

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Year:  1994        PMID： 8151648      PMCID： PMC1049609          DOI： 10.1136/jmg.31.1.81

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  8 in total

1.  Nucleotide sequencing of HLA-DQ gene second exons in Chinese homozygous cells.

Authors:  Y Wang; P Lu; K Zhou; T Clay; N Wood; B Bradley; J Bidwell
Journal:  Eur J Immunogenet       Date:  1992-10

2.  Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter.

Authors:  F P Lemaigre; D A Lafontaine; S J Courtois; S M Durviaux; G G Rousseau
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

3.  Isolated growth hormone deficiency type 1A in a Japanese family.

Authors:  Y Nishi; K Aihara; T Usui; J A Phillips; R L Mallonee; C J Migeon
Journal:  J Pediatr       Date:  1984-06       Impact factor: 4.406

4.  The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.

Authors:  P H Seeburg
Journal:  DNA       Date:  1982

5.  Familial growth hormone deficiency resulting from a 7.6 kb deletion within the growth hormone gene cluster.

Authors:  S Braga; J A Phillips; E Joss; H Schwarz; K Zuppinger
Journal:  Am J Med Genet       Date:  1986-11

6.  A Chinese familial growth hormone deficiency with a deletion of 7.1 kb of DNA.

Authors:  Y A He; S S Chen; Y X Wang; X Y Lin; D F Wang
Journal:  J Med Genet       Date:  1990-03       Impact factor: 6.318

7.  Molecular basis for familial isolated growth hormone deficiency.

Authors:  J A Phillips; B L Hjelle; P H Seeburg; M Zachmann
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

8.  Human growth hormone DNA sequence and mRNA structure: possible alternative splicing.

Authors:  F M DeNoto; D D Moore; H M Goodman
Journal:  Nucleic Acids Res       Date:  1981-08-11       Impact factor: 16.971
  8 in total

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