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Literature DB >> 6269091

Human growth hormone DNA sequence and mRNA structure: possible alternative splicing.

Abstract

We have determined the complete sequence of the human growth hormone (hGH) gene and the position of the mature 5' end of the hGH mRNA within the sequence. Comparison of this sequence with that of a cloned hGH cDNA shows that the gene is interrupted by four intervening sequences. S1 mapping shows that one of these intervening sequences has two different 3' splice sites. These alternate splicing pathways generate hGH peptides of different sizes which are found in normal pituitaries. Comparison of sequences near the 5' end of the hGH mRNA with a similar region of the alpha subunit of the human glycoprotein hormones reveals an unexpected region of homology between these otherwise unrelated peptide hormones.

Entities: Gene Species

Mesh：

Substances：

Year: 1981 PMID： 6269091 PMCID： PMC327387 DOI： 10.1093/nar/9.15.3719

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

30 in total

1. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.

Authors: H Sakano; J H Rogers; K Hüppi; C Brack; A Traunecker; R Maki; R Wall; S Tonegawa
Journal: Nature Date: 1979-02-22 Impact factor: 49.962

2. Human growth hormone: additional members of the complex.

Authors: U J Lewis; R N Singh; L F Bonewald; L J Lewis; W P Vanderlaan
Journal: Endocrinology Date: 1979-05 Impact factor: 4.736

3. Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

Authors: S Tonegawa; A M Maxam; R Tizard; O Bernard; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1978-03 Impact factor: 11.205

4. The ovalbumin gene: cloning and molecular organization of the entire natural gene.

Authors: A Dugaiczyk; S L Woo; D A Colbert; E C Lai; M L Mace; B W O'Malley
Journal: Proc Natl Acad Sci U S A Date: 1979-05 Impact factor: 11.205

5. 3' non-coding region sequences in eukaryotic messenger RNA.

Authors: N J Proudfoot; G G Brownlee
Journal: Nature Date: 1976-09-16 Impact factor: 49.962

Review 6. The regulation of growth by endocrines.

Authors: W H Daughaday; A C Herington; L S Phillips
Journal: Annu Rev Physiol Date: 1975 Impact factor: 19.318

7. Why genes in pieces?

Authors: W Gilbert
Journal: Nature Date: 1978-02-09 Impact factor: 49.962

8. Construction and analysis of recombinant DNA for human chorionic somatomammotropin.

Authors: J Shine; P H Seeburg; J A Martial; J D Baxter; H M Goodman
Journal: Nature Date: 1977-12-08 Impact factor: 49.962

9. Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

Authors: R Breathnach; C Benoist; K O'Hare; F Gannon; P Chambon
Journal: Proc Natl Acad Sci U S A Date: 1978-10 Impact factor: 11.205

10. Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication.

Authors: H D Niall; M L Hogan; R Sauer; I Y Rosenblum; F C Greenwood
Journal: Proc Natl Acad Sci U S A Date: 1971-04 Impact factor: 11.205

90 in total

1. Epstein-Barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA.

Authors: V Ruvolo; A K Gupta; S Swaminathan
Journal: J Virol Date: 2001-07 Impact factor: 5.103

2. Functional analysis of Epstein-Barr virus SM protein: identification of amino acids essential for structure, transactivation, splicing inhibition, and virion production.

Authors: Vivian Ruvolo; Liang Sun; Karilynn Howard; Seung Sung; Henri-Jacques Delecluse; Wolfgang Hammerschmidt; Sankar Swaminathan
Journal: J Virol Date: 2004-01 Impact factor: 5.103

10. A GC-rich domain with bifunctional effects on mRNA and protein levels: implications for control of transforming growth factor beta 1 expression.

Authors: L Scotto; R K Assoian
Journal: Mol Cell Biol Date: 1993-06 Impact factor: 4.272

Human growth hormone DNA sequence and mRNA structure: possible alternative splicing.

1. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.

2. Human growth hormone: additional members of the complex.

3. Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

4. The ovalbumin gene: cloning and molecular organization of the entire natural gene.

5. 3' non-coding region sequences in eukaryotic messenger RNA.

Review 6. The regulation of growth by endocrines.

7. Why genes in pieces?

8. Construction and analysis of recombinant DNA for human chorionic somatomammotropin.

9. Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

10. Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication.

1. Epstein-Barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA.

2. Functional analysis of Epstein-Barr virus SM protein: identification of amino acids essential for structure, transactivation, splicing inhibition, and virion production.

3. Cloning and nucleotide sequence of a cDNA encoding the mink growth hormone.

Review 4. One hundred years of pleiotropy: a retrospective.

5. Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas.

6. Coding potential of transfected human placental lactogen genes.

7. Neural network detects errors in the assignment of mRNA splice sites.

8. Plant cells do not properly recognize animal gene polyadenylation signals.

9. Structure and function of a new class of human prolactin antagonists.

10. A GC-rich domain with bifunctional effects on mRNA and protein levels: implications for control of transforming growth factor beta 1 expression.