| Literature DB >> 8145287 |
W H Wolfe, J E Michalek, J C Miner, J L Pirkle, S P Caudill, D G Patterson, L L Needham.
Abstract
The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that half-life increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.Entities:
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Year: 1994 PMID： 8145287 DOI： 10.1080/15287399409531858
Source DB: PubMed Journal: J Toxicol Environ Health ISSN： 0098-4108