| Literature DB >> 8145229 |
T C McKee1, J H Cardellina, R Riccio, M V D'Auria, M Iorizzi, L Minale, R A Moran, R J Gulakowski, J B McMahon, R W Buckheit.
Abstract
A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM against HIV-1 (RF) and 2-8 microM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.Entities:
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Year: 1994 PMID： 8145229 DOI： 10.1021/jm00032a012
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446