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Literature DB >> 29184120

Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.

Fumiaki Nakamura¹, Norio Kudo², Yuki Tomachi¹, Akiko Nakata², Misao Takemoto², Akihiro Ito^3,4, Hodaka Tabei¹, Daisuke Arai⁵, Nicole de Voogd⁶, Minoru Yoshida^2,3,7, Yoichi Nakao^1,5, Nobuhiro Fusetani^5,8.

Abstract

Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.

Entities: Chemical Disease Gene

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Year: 2017 PMID： 29184120 DOI： 10.1038/ja.2017.145

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.

Review 1. Sirtuins in metabolism, stemness and differentiation.

2. Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica.

3. Unusual cyclolanostanes from leaves of Pandanus boninensis.

4. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.

5. Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.

Review 6. The sirtuin family's role in aging and age-associated pathologies.

7. Features and development of Coot.

8. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.

9. Novel HIV-inhibitory halistanol sulfates F-H from a marine sponge, Pseudoaxinissa digitata.

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