Literature DB >> 20560563

Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta.

Emily L Whitson1, Tim S Bugni, Priya S Chockalingam, Gisela P Concepcion, Xidong Feng, Guixian Jin, Mary Kay Harper, Gina C Mangalindan, Leonard A McDonald, Chris M Ireland.   

Abstract

Three new sulfated sterol dimers, fibrosterol sulfates A-C (1-3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhibited PKCzeta with IC(50) values of 16.4 and 5.6 microM, respectively.

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Year:  2009        PMID： 20560563      PMCID： PMC2889921          DOI： 10.1021/jo900844r

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  24 in total

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5.  Marine natural products: pyrrololactams from several sponges.

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6.  Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.

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8.  Pivotal Advance: PKCzeta is required for migration of macrophages.

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Journal:  J Leukoc Biol       Date:  2009-02-06       Impact factor: 4.962

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Authors:  Y Mimaki; M Kuroda; T Fukasawa; Y Sashida
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10.  Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.

Authors:  Emily L Whitson; Tim S Bugni; Priya S Chockalingam; Gisela P Concepcion; Mary Kay Harper; Min He; John N A Hooper; Gina C Mangalindan; Frank Ritacco; Chris M Ireland
Journal:  J Nat Prod       Date:  2008-06-18       Impact factor: 4.050
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  6 in total

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Review 2.  Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.

Authors:  H C Ringvold; R A Khalil
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3.  Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A.

Authors:  Han Sun; Uwe M Reinscheid; Emily L Whitson; Edward J d'Auvergne; Chris M Ireland; Armando Navarro-Vázquez; Christian Griesinger
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Review 4.  Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease.

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Journal:  Biochem Pharmacol       Date:  2018-02-13       Impact factor: 5.858

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Review 6.  Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile.

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  6 in total

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