Discrimination of folding types of globular proteins based on average distance maps constructed from their sequences.

It has been shown that probable portions which form contacts in a protein can be predicted by means of an average distance map (ADM) as well as regular structures (alpha-helices and beta-turns) defined as short-range compact regions (Kikuchi et al., 1988a,c). In this paper, we analyze the occurrence of those portions and short-range compact regions on ADMs for various proteins regarding their folding types. We have found out that each folding type of proteins shows characteristic distribution of such parts on ADMs. We also discuss the possibility of the prediction of folding types of proteins by ADMs.