| Literature DB >> 6991952 |
F E Cohen, M J Sternberg, W R Taylor.
Abstract
Analysis of beta-sheet sandwiches (for example immunoglobulin domains) suggests an algorithm that successfully predicts the tertiary fold of these proteins from their sequence and secondary structure. We propose tertiary structures for beta 2-microglobulin and an HLA-B7 antigen fragment. Topological rules are presented that markedly reduce the number of folds for proteins in which a-helices pack against a parallel beta-sheet.Entities:
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Year: 1980 PMID: 6991952 DOI: 10.1038/285378a0
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962