| Literature DB >> 8136326 |
J M Bernassau1, J L Reversat, P Ferrara, D Caput, G Lefur.
Abstract
A three-dimensional (3D) model of the peripheral benzodiazepine receptor (PBR) has been built using molecular dynamics simulations. The transmembrane domain of the receptor has been modeled as five alpha-helices, which are not long enough to cross the entire bilayer membrane but correspond approximately to only one phospholipid layer. The receptor model has also been tested as a cholesterol carrier, and molecular dynamics simulations have shown that it could indeed accommodate a cholesterol molecule within the five helices. All three known PBR sequences have been modeled, and no significant difference has been found between them.Entities:
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Year: 1993 PMID： 8136326 DOI： 10.1016/0263-7855(93)80003-a
Source DB: PubMed Journal: J Mol Graph ISSN： 0263-7855