Literature DB >> 21119734

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.

Rainer Rupprecht1, Vassilios Papadopoulos, Gerhard Rammes, Thomas C Baghai, Jinjiang Fan, Nagaraju Akula, Ghislaine Groyer, David Adams, Michael Schumacher.   

Abstract

The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system. One of its main functions is the transport of the substrate cholesterol into mitochondria, a prerequisite for steroid synthesis. TSPO expression may constitute a biomarker of brain inflammation and reactive gliosis that could be monitored by using TSPO ligands as neuroimaging agents. Moreover, initial clinical trials have indicated that TSPO ligands might be valuable in the treatment of neurological and psychiatric disorders. This Review focuses on the biology and pathophysiology of TSPO and the potential of currently available TSPO ligands for the diagnosis and treatment of neurological and psychiatric disorders.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 21119734     DOI： 10.1038/nrd3295

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  204 in total

1.  Increased peripheral benzodiazepine binding sites and pentraxin 3 expression in the spinal cord during EAE: relation to inflammatory cytokines and modulation by dexamethasone and rolipram.

Authors:  D Agnello; L Carvelli; V Muzio; P Villa; B Bottazzi; N Polentarutti; T Mennini; A Mantovani; P Ghezzi
Journal:  J Neuroimmunol       Date:  2000-09-22       Impact factor: 3.478

2.  2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats.

Authors:  M Serra; P Madau; M F Chessa; M Caddeo; E Sanna; G Trapani; M Franco; G Liso; R H Purdy; M L Barbaccia; G Biggio
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

3.  Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.

Authors:  S Giatti; M Pesaresi; G Cavaletti; R Bianchi; V Carozzi; R Lombardi; O Maschi; G Lauria; L M Garcia-Segura; D Caruso; R C Melcangi
Journal:  Neuroscience       Date:  2009-08-07       Impact factor: 3.590

4.  The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line.

Authors:  Evgeny Levin; Arumugam Premkumar; Leo Veenman; Wilfried Kugler; Svetlana Leschiner; Ilana Spanier; Gary Weisinger; Max Lakomek; Abraham Weizman; Solomon H Snyder; Gavril W Pasternak; Moshe Gavish
Journal:  Biochemistry       Date:  2005-07-26       Impact factor: 3.162

5.  Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus.

Authors:  K A Wafford; M B van Niel; Q P Ma; E Horridge; M B Herd; D R Peden; D Belelli; J J Lambert
Journal:  Neuropharmacology       Date:  2008-08-13       Impact factor: 5.250

6.  Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus.

Authors:  Enrico Sanna; Giuseppe Talani; Fabio Busonero; Maria Giuseppina Pisu; Robert H Purdy; Mariangela Serra; Giovanni Biggio
Journal:  J Neurosci       Date:  2004-07-21       Impact factor: 6.167

Review 7.  Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties.

Authors:  R Rupprecht
Journal:  Psychoneuroendocrinology       Date:  2003-02       Impact factor: 4.905

8.  Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106.

Authors:  Fumihiko Yasuno; Miho Ota; Jun Kosaka; Hiroshi Ito; Makoto Higuchi; Talant K Doronbekov; Shoko Nozaki; Yota Fujimura; Michihiko Koeda; Takashi Asada; Tetsuya Suhara
Journal:  Biol Psychiatry       Date:  2008-06-02       Impact factor: 13.382

9.  Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.

Authors:  V Papadopoulos; P Guarneri; K E Kreuger; A Guidotti; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

Review 10.  Visualising microglial activation in vivo.

Authors:  Richard B Banati
Journal:  Glia       Date:  2002-11       Impact factor: 8.073
View more
  322 in total

1.  Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates.

Authors:  Jonas Hannestad; Jean-Dominique Gallezot; Thomas Schafbauer; Keunpoong Lim; Tracy Kloczynski; Evan D Morris; Richard E Carson; Yu-Shin Ding; Kelly P Cosgrove
Journal:  Neuroimage       Date:  2012-07-06       Impact factor: 6.556

Review 2.  The Bidirectional Relationship of Depression and Inflammation: Double Trouble.

Authors:  Eléonore Beurel; Marisa Toups; Charles B Nemeroff
Journal:  Neuron       Date:  2020-06-17       Impact factor: 17.173

3.  Translocator protein 18 kDa negatively regulates inflammation in microglia.

Authors:  Keun-Ryung Bae; Hyun-Jung Shim; Deebika Balu; Sang Ryong Kim; Seong-Woon Yu
Journal:  J Neuroimmune Pharmacol       Date:  2014-04-01       Impact factor: 4.147

4.  The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.

Authors:  Lora D Weidner; Pavitra Kannan; Nicholas Mitsios; Sun J Kang; Matthew D Hall; William H Theodore; Robert B Innis; Jan Mulder
Journal:  Epilepsia       Date:  2018-07-21       Impact factor: 5.864

5.  Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances.

Authors:  Daisuke Fukudome; Lindsay N Hayes; Travis E Faust; Catherine A Foss; Mari A Kondo; Brian J Lee; Atsushi Saito; Shin-Ichi Kano; Jennifer M Coughlin; Atsushi Kamiya; Martin G Pomper; Akira Sawa; Minae Niwa
Journal:  Schizophr Res       Date:  2018-02-03       Impact factor: 4.939

Review 6.  Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets.

Authors:  Alexandra Grubman; Katja M Kanninen; Tarja Malm
Journal:  J Mol Neurosci       Date:  2016-09-22       Impact factor: 3.444

7.  Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J mice.

Authors:  A Leslie Morrow; C J Malanga; Eric W Fish; Buddy J Whitman; Jeff F DiBerto; J Elliott Robinson
Journal:  Psychopharmacology (Berl)       Date:  2014-05-09       Impact factor: 4.530

8.  Preclinical in vivo and in vitro comparison of the translocator protein PET ligands [18F]PBR102 and [18F]PBR111.

Authors:  S Eberl; A Katsifis; M A Peyronneau; L Wen; D Henderson; C Loc'h; I Greguric; J Verschuer; T Pham; P Lam; F Mattner; A Mohamed; M J Fulham
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-10-04       Impact factor: 9.236

9.  [18F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer.

Authors:  Neydher Berroterán-Infante; Theresa Balber; Petra Fürlinger; Michael Bergmann; Rupert Lanzenberger; Marcus Hacker; Markus Mitterhauser; Wolfgang Wadsak
Journal:  ACS Med Chem Lett       Date:  2018-02-21       Impact factor: 4.345

Review 10.  Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.

Authors:  Vijay K Ramanan; Andrew J Saykin
Journal:  Am J Neurodegener Dis       Date:  2013-09-18
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.